ArticleScientific reports2016
Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Chemogenetic Schwann cell activation impairs early myelination and triggers adult demyelination in the peripheral nervous system.Frontiers in cellular neuroscience · 2026Article
- 5-HT1B receptor agonists promote Schwann cell myelination.PloS one · 2026Article
- PMP2 Enhances Schwann Cell Metabolism and Promotes Myelination.Journal of neurochemistry · 2025Article
- GRM2 Regulates Functional Integration of Adult-Born DGCs by Paradoxically Modulating MEK/ERK1/2 Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cellular mechanisms of heterogeneity in NF2-mutant schwannoma.Nature communications · 2023Article
- Emerging Roles of Cholinergic Receptors in Schwann Cell Development and Plasticity.Biomedicines · 2022Review
- Glutamatergic systems in neuropathic pain and emerging non-opioid therapies.Pharmacological research · 2022Review
- Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.The Journal of clinical investigation · 2021Article
- Glutamate receptors and glutamatergic signalling in the peripheral nerves.Neural regeneration research · 2020Review
- Metabolic Interaction Between Schwann Cells and Axons Under Physiological and Disease Conditions.Frontiers in cellular neuroscience · 2020Article
- Cannabinoid Receptor 2 (CBACS pharmacology & translational science · 2019Article
- Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease.International journal of molecular sciences · 2019Review
- Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation.Acta pharmacologica Sinica · 2019Article
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- Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid saltatory nerve conduction is facilitated by myelin structure, which is produced by Schwann cells (SC) in the peripheral nervous system (PNS). Proper development and degeneration/regeneration after injury requires regulated phenotypic changes of SC. We have previously shown that glutamate can induce SC proliferation in culture. Here we show that glutamate signals through metabotropic glutamate receptor 2 (mGluR2) to induce Erk phosphorylation in SC. mGluR2-elicited Erk phosphorylation requires ErbB2/3 receptor tyrosine kinase phosphorylation to limit the signaling cascade that promotes phosphorylation of Erk, but not Akt. We found that Gβγ and Src are involved in subcellular signaling downstream of mGluR2. We also found that glutamate can transform myelinating SC to proliferating SC, while inhibition of mGluR2 signaling can inhibit demyelination of injured nerves in vivo. These data suggest pathophysiological significance of mGluR2 signaling in PNS and its possible therapeutic importance to combat demyelinating disorders including Charcot-Marie-Tooth disease.
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Registered trials
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