ArticleGenome research2016
Recent independent emergence of multiple multidrug-resistant Serratia marcescens clones within the United Kingdom and Ireland.
Article in Genome research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
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- Infection characteristics amongmBio · 2025Article
- Infection characteristics amongbioRxiv : the preprint server for biology · 2025Article
- Competitive behaviors in Serratia marcescens are coordinately regulated by a lifestyle switch frequently inactivated in the clinical environment.Cell host & microbe · 2025Article
- Genomes of novelMicrobiology resource announcements · 2025Article
- Global genomic epidemiology and plasmid-mediated dissemination ofCurrent research in microbial sciences · 2025Article
- Molecular epidemiology of a carbapenem-resistantFrontiers in microbiology · 2025Article
- Genome-resolved analysis of Serratia marcescens strain SMTT infers niche specialization as a hydrocarbon-degrader.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Article
- Genetic barriers more than environmental associations explain Serratia marcescens population structure.Communications biology · 2024Article
- RETRACTED: Effects of negative-pressure wound therapy in the prevention of surgical-site wound infection after vascular surgery: A meta-analysis.International wound journal · 2024Article
- Diversity of antimicrobial-resistant bacteria isolated from Australian chicken and pork meat.Frontiers in microbiology · 2024Article
- Antimicrobial Resistance Pattern, Predisposing Factors, and Outcome of Serratia Infection in Patients Treated at a Secondary-Care Hospital in Oman: A 5-Year Retrospective Study.Advanced biomedical research · 2024Article
- Systematic analysis of plasmids of theMicrobial genomics · 2023Article
- Molecular Typing ofJournal of pharmacy & bioallied sciences · 2023Article
- Neonatal Brain Abscess withAntibiotics (Basel, Switzerland) · 2023Article
- The man, the plant, and the insect: shooting host specificity determinants inFrontiers in microbiology · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
Serratia marcescens, a member of the Enterobacteriaceae family, is a Gram-negative bacterium responsible for a wide range of nosocomial infections. The emergence of multidrug-resistant strains is an increasing danger to public health. To design effective means to control the dissemination of S. marcescens, an in-depth analysis of the population structure and variation is required. Utilizing whole-genome sequencing, we characterized the population structure and variation, as well as the antimicrobial resistance determinants, of a systematic collection of antimicrobial-resistant S. marcescens associated with bloodstream infections in hospitals across the United Kingdom and Ireland between 2001 and 2011. Our results show that S. marcescens is a diverse species with a high level of genomic variation. However, the collection was largely composed of a limited number of clones that emerged from this diverse background within the past few decades. We identified potential recent transmissions of these clones, within and between hospitals, and showed that they have acquired antimicrobial resistance determinants for different beta-lactams, ciprofloxacin, and tetracyclines on multiple occasions. The expansion of these multidrug-resistant clones suggests that the treatment of S. marcescens infections will become increasingly difficult in the future.
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