ArticleScientific reports2016
Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 91 citations in OpenAlex.
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- Temporal evolution of insecticide resistance and bionomics in Anopheles funestus, a key malaria vector in Uganda.Scientific reports · 2024Article
- Virulence and transmission vary between Usutu virus lineages in Culex pipiens.PLoS neglected tropical diseases · 2024Article
- Mosquito ageing modulates the development, virulence and transmission potential of pathogens.Proceedings. Biological sciences · 2024Article
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- The dynamics of deltamethrin resistance evolution in Aedes albopictus has an impact on fitness and dengue virus type-2 vectorial capacity.BMC biology · 2023Article
- Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles.PLoS pathogens · 2023Article
- Intervention reducing malaria parasite load in vector mosquitoes: No impact on Plasmodium falciparum extrinsic incubation period and the survival of Anopheles gambiae.PLoS pathogens · 2023Article
- Impact of insecticide resistance on malaria vector competence: a literature review.Malaria journal · 2023Review
- Efficacy ofJournal of parasitology research · 2023Article
- Mathematics of a single-locus model for assessing the impacts of pyrethroid resistance and temperature on population abundance of malaria mosquitoes.Infectious Disease Modelling · 2022Article
- AGenes · 2022Article
- Use of novel lab assays to examine the effect of pyrethroid-treated bed nets on blood-feeding success and longevity of highly insecticide-resistant Anopheles gambiae s.l. mosquitoes.Parasites & vectors · 2022Article
- LLIN evaluation in Uganda project (LLINEUP): The fabric integrity, chemical content and bioefficacy of long-lasting insecticidal nets treated with and without piperonyl butoxide across two years of operational use in Uganda.Current research in parasitology & vector-borne diseases · 2022Article
- Evaluation of the interaction between insecticide resistance-associated genes and malaria transmission in Anopheles gambiae sensu lato in central Côte d'Ivoire.Parasites & vectors · 2021Article
- Review
- Impact of deltamethrin-resistance in Aedes albopictus on its fitness cost and vector competence.PLoS neglected tropical diseases · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insecticide resistance raises concerns for the control of vector-borne diseases. However, its impact on parasite transmission could be diverse when considering the ecological interactions between vector and parasite. Thus we investigated the fitness cost associated with insecticide resistance and Plasmodium falciparum infection as well as their interactive cost on Anopheles gambiae survival and fecundity. In absence of infection, we observed a cost on fecundity associated with insecticide resistance. However, survival was higher for mosquito bearing the kdr mutation and equal for those with the ace-1(R) mutation compared to their insecticide susceptible counterparts. Interestingly, Plasmodium infection reduced survival only in the insecticide resistant strains but not in the susceptible one and infection was associated with an increase in fecundity independently of the strain considered. This study provides evidence for a survival cost associated with infection by Plasmodium parasite only in mosquito selected for insecticide resistance. This suggests that the selection of insecticide resistance mutation may have disturbed the interaction between parasites and vectors, resulting in increased cost of infection. Considering the fitness cost as well as other ecological aspects of this natural mosquito-parasite combination is important to predict the epidemiological impact of insecticide resistance.
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