ArticleHead & neck2016
Cigarette use, comorbidities, and prognosis in a prospective head and neck squamous cell carcinoma population.
Article in Head & neck, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis.In vivo (Athens, Greece)Pooled it
- Pembrolizumab With or Without Chemotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Updated Results of the Phase III KEYNOTE-048 Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Trial
- The importance of HPV testing in oropharyngeal cancer in two US populations.Neoplasia (New York, N.Y.) · 2026Article
- Impact of neighbor-level disadvantage on survival outcomes in head and neck squamous cell carcinoma.Cancer causes & control : CCC · 2025Article
- Advancements in Hyperspectral Imaging and Computer-Aided Diagnostic Methods for the Enhanced Detection and Diagnosis of Head and Neck Cancer.Biomedicines · 2024Review
- Aspirin use and head and neck cancer survival and recurrence.Cancer causes & control : CCC · 2024Article
- Eugene Nicholas Myers' Lecture on Head and Neck Cancer, 2020: The Surgeon as a Prognostic Factor in Head and Neck Cancer Patients Undergoing Surgery.International archives of otorhinolaryngology · 2023Article
- The Intratumor Bacterial and Fungal Microbiome Is Characterized by HPV, Smoking, and Alcohol Consumption in Head and Neck Squamous Cell Carcinoma.International journal of molecular sciences · 2022Article
- The association between inflammatory biomarkers and statin use among patients with head and neck squamous cell carcinoma.Head & neck · 2022Article
- Impact of human immunodeficiency virus status on laryngeal cancer survival and locoregional control.Laryngoscope investigative otolaryngology · 2022Article
- A stacked approach for chained equations multiple imputation incorporating the substantive model.Biometrics · 2021Article
- Quantifying smoking exposure, genomic correlates, and related risk of treatment failure in p16+ squamous cell carcinoma of the oropharynx.Laryngoscope investigative otolaryngology · 2021Article
- Development and Assessment of a Model for Predicting Individualized Outcomes in Patients With Oropharyngeal Cancer.JAMA network open · 2021Article
- Statin use and head and neck squamous cell carcinoma outcomes.International journal of cancer · 2021Article
- Diagnostic and prognostic value ofJournal of Cancer · 2021Article
- Article
- Alteration of smoking habit at time of first diagnosis influences survival of patients with HNSCC.Molecular and clinical oncology · 2020Article
- A case study of salivary microbiome in smokers and non-smokers in Hungary: analysis by shotgun metagenome sequencing.Journal of oral microbiology · 2020Article
- High nodal FDG uptake increases risk of distant metastasis in patients with oropharyngeal squamous cell carcinoma.European journal of nuclear medicine and molecular imaging · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundTo better understand the associations between a history of tobacco use and survival outcomes, cigarette use was prospectively surveyed in 687 previously untreated patients with cancer of the oral cavity (n = 271), oropharynx (n = 257), larynx (n = 135), or hypopharynx (n = 24).
methodsKaplan-Meier and Cox models explored the associations of tobacco use intensity (packs/day), duration (years of use), and timing before diagnosis with overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).
resultsCigarette use duration, timing, and intensity were significant predictors for all outcomes in univariate analysis. Never smoking and pack-years were not significantly associated with outcomes after adjustment for prognostic factors, such as stage, comorbidities, and human papillomavirus (HPV) status, which were strongly associated with clinical outcomes.
conclusionThe findings confirm the association between smoking history and survival and the importance of clinical variables in evaluating smoking as a prognostic factor. Timing, intensity, and duration of cigarette use should be considered with other prognostic factors when considering risk stratification for treatment planning. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1810-1820, 2016.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.