ArticleeLife2016
Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
- Article
- Probing multiplexed basal dendritic computations using two-photon 3D holographic uncaging.Cell reports · 2024Article
- Mechanisms regulating the properties of inhibition-based gamma oscillations in primate prefrontal and parietal cortices.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Different resting membrane potentials in posterior parietal cortex and prefrontal cortex in the view of recurrent synaptic strengths and neural network dynamics.Frontiers in cellular neuroscience · 2023Article
- Spatial integration of dendrites in fast-spiking basket cells.Frontiers in neuroscience · 2023Article
- Astrocytes Learn to Detect and Signal Deviations From Critical Brain Dynamics.Neural computation · 2022Article
- Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons.Neuron · 2022Article
- Classical-Contextual Interactions in V1 May Rely on Dendritic Computations.Neuroscience · 2022Article
- Emergence of synaptic organization and computation in dendrites.Neuroforum · 2022Review
- Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.Neuron · 2021Article
- Active dendrites enable strong but sparse inputs to determine orientation selectivity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Convergence Circuit Mapping: Genetic Approaches From Structure to Function.Frontiers in systems neuroscience · 2021Review
- Dendritic Integration Dysfunction in Neurodevelopmental Disorders.Developmental neuroscience · 2021Review
- Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.Frontiers in neural circuits · 2021Review
- Neuronal Activity at Synapse Resolution: Reporters and Effectors for Synaptic Neuroscience.Frontiers in molecular neuroscience · 2020Review
- Distinct Properties of Layer 3 Pyramidal Neurons from Prefrontal and Parietal Areas of the Monkey Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.Science (New York, N.Y.) · 2019Article
- Synaptic Clustering and Memory Formation.Frontiers in molecular neuroscience · 2019Review
- The development of local circuits in the neocortex: recent lessons from the mouse visual cortex.Current opinion in neurobiology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spatial organization of synaptic inputs on the dendritic tree of cortical neurons plays a major role for dendritic integration and neural computations, yet, remarkably little is known about it. We mapped the spatial organization of glutamatergic synapses between layer 5 pyramidal cells by combining optogenetics and 2-photon calcium imaging in mouse neocortical slices. To mathematically characterize the organization of inputs we developed an approach based on combinatorial analysis of the likelihoods of specific synapse arrangements. We found that the synapses of intralaminar inputs form clusters on the basal dendrites of layer 5 pyramidal cells. These clusters contain 4 to 14 synapses within ≤30 µm of dendrite. According to the spatiotemporal characteristics of synaptic summation, these numbers suggest that there will be non-linear dendritic integration of synaptic inputs during synchronous activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.