SynthesisClinical cardiology2016
The Prognostic Impact of New-Onset Persistent Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation: A Meta-analysis.
Synthesis in Clinical cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Predictors of Permanent Pacemaker Implantation in Patients Undergoing Transcatheter Aortic Valve Replacement - A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2021Pooled it
- Delayed bradycardia-dependent left bundle branch block after transcatheter aortic valve implantation: A potential indication for permanent pacing.HeartRhythm case reports · 2026Article
- A Transformer-Based Machine Learning Framework for Risk Stratification of Left Bundle Branch Block After Transcatheter Aortic Valve Replacement.Diagnostics (Basel, Switzerland) · 2026Article
- Management of conduction disturbances after TAVI: the last step towards early discharge.Journal of geriatric cardiology : JGC · 2025Article
- Impact of New-Onset Right Bundle-Branch Block After Transcatheter Aortic Valve Replacement on Permanent Pacemaker Implantation.Journal of the American Heart Association · 2024Article
- LDL-C: An Important Independent Risk Factor for New-Onset Heart Block in Patients with Severe Aortic Stenosis and Heart Failure after TAVR.Reviews in cardiovascular medicine · 2023Article
- Transcatheter Aortic Valve Replacement in Elderly Patients: Opportunities and Challenges.Journal of cardiovascular development and disease · 2023Review
- Unmet Needs in TAVR: Conduction Disturbances and Management of Coronary Artery Disease.Journal of clinical medicine · 2022Review
- Occurrence and Persistency of Conduction Disturbances during Transcatheter Aortic Valve Implantation.Medicina (Kaunas, Lithuania) · 2021Article
- Electrophysiology Testing to Stratify Patients With Left Bundle Branch Block After Transcatheter Aortic Valve Implantation.Journal of the American Heart Association · 2020Article
- Impact of Complications During Transfemoral Transcatheter Aortic Valve Replacement: How Can They Be Avoided and Managed?Journal of the American Heart Association · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New-onset persistent left bundle branch block (NOP-LBBB) is one of the most common conduction disturbances after transcatheter aortic valve implantation (TAVI). We hypothesized that NOP-LBBB may have a clinically negative impact after TAVI. To find out, we conducted a systematic literature search of the MEDLINE/PubMed and Embase databases. Observational studies that reported clinical outcomes of NOP-LBBB patients after TAVI were included. The random-effects model was used to combine odds ratios, risk ratios, or hazard ratios (HRs) with 95% confidence intervals. Adjusted HRs were utilized over unadjusted HRs or risk ratios when available. A total of 4049 patients (807 and 3242 patients with and without NOP-LBBB, respectively) were included. Perioperative (in-hospital or 30-day) and midterm all-cause mortality and midterm cardiovascular mortality were comparable between the groups. The NOP-LBBB patients experienced a higher rate of permanent pacemaker implantation (HR: 2.09, 95% confidence interval: 1.12-3.90, P = 0.021, I(2) = 83%) during midterm follow-up. We found that NOP-LBBB after TAVI resulted in higher permanent pacemaker implantation but did not negatively affect the midterm prognosis. Therefore, careful observation during the follow-up is required.
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Registered trials
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