ArticleScientific reports2016
Novel avian influenza A (H5N6) viruses isolated in migratory waterfowl before the first human case reported in China, 2014.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A literature review of the use of environmental sampling in the surveillance of avian influenza viruses.Transboundary and emerging diseases · 2021Pooled it
- Unique phenomenon of H5 highly pathogenic avian influenza virus in China: co-circulation of Clade 2.3.4.4b H5N1 and H5N6 results in diversity of H5 Virus.Emerging microbes & infections · 2025Article
- Origin and cross-species transmission of bat coronaviruses in China.Nature communications · 2024Article
- Epidemiological characteristics of human infections with avian influenza A(H5N6) virus, China and Laos: A multiple case descriptive analysis, February 2014-June 2023.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2024Article
- Exploring the global immune landscape of peripheral blood mononuclear cells in H5N6-infected patient with single-cell transcriptomics.BMC medical genomics · 2023Article
- Bidirectional Movement of Emerging H5N8 Avian Influenza Viruses Between Europe and Asia via Migratory Birds Since Early 2020.Molecular biology and evolution · 2023Article
- Emergence of H5N8 avian influenza virus in domestic geese in a wild bird habitat, Yishui Lake, north central China.Virologica Sinica · 2023Article
- Key amino acid position 272 in neuraminidase determines the replication and virulence of H5N6 avian influenza virus in mammals.iScience · 2022Article
- Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges.Innovation (Cambridge (Mass.)) · 2022Review
- Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China.Emerging infectious diseases · 2022Article
- Prevalence and risk factors of Avian Influenza Viruses among household ducks in Chattogram, Bangladesh.Veterinary research communications · 2022Article
- H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans.PLoS pathogens · 2021Article
- Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China.Emerging microbes & infections · 2021Article
- Isolation and characterization of two novel reassortant H5N6 avian influenza viruses from waterfowl in eastern China.Archives of virology · 2021Article
- Antibodies to Highly Pathogenic A/H5Nx (Clade 2.3.4.4) Influenza Viruses in the Sera of Vietnamese Residents.Pathogens (Basel, Switzerland) · 2021Article
- Diversity of avian influenza A(H5N6) viruses in wild birds in southern China.The Journal of general virology · 2020Article
- Origin and cross-species transmission of bat coronaviruses in China.Nature communications · 2020Article
- Genetic diversity, phylogeography, and evolutionary dynamics of highly pathogenic avian influenza A (H5N6) viruses.Virus evolution · 2020Article
- Article
- Contribution of Fc-dependent cell-mediated activity of a vestigial esterase-targeting antibody against H5N6 virus infection.Emerging microbes & infections · 2020Article
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Abstract
In May 2014, China formally confirmed the first human infection with the novel H5N6 avian influenza virus (AIV) in Sichuan Province. Before the first human case was reported, surveillance of AIVs in wild birds resulted in the detection of three H5N6 viruses in faecal samples from migratory waterfowl in Chenhu wetlands, Hubei Province, China. Genetic and phylogenetic analyses revealed that these three novel viruses were closely related to the H5N6 virus that has caused human infections in China since 2014. A Bayesian phylogenetic reconstruction of all eight segments suggests multiple reassortment events in the evolution of these viruses. The hemagglutinin (HA) and neuraminidase (NA) originated from the H5N2 and H6N6 AIVs, respectively, whereas all six internal genes were derived from avian H5N1 viruses. The reassortant may have occurred in eastern China during 2012-2013. A phylogeographic analysis of the HA and NA genes traced the viruses to southern China, from where they spread to other areas via eastern China. A receptor-binding test showed that H5N6 viruses from migratory waterfowl had human-type receptor-binding activity, suggesting a potential for transmission to humans. These data suggest that migratory waterfowl may play a role in the dissemination of novel H5N6 viruses.
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