ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Generating minimal living systems from non-living materials and increasing their evolutionary abilities.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Protocellular energy transduction, information and fitness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Protocells Either Synchronize or Starve.Entropy (Basel, Switzerland) · 2025Article
- Public attitudes to potential synthetic cells applications: Pragmatic support and ethical acceptance.PloS one · 2025Article
- Models of Protocells Undergoing Asymmetrical Division.Entropy (Basel, Switzerland) · 2024Article
- The Conception of Synthetic Entities from a Personalist Perspective.Science and engineering ethics · 2019Article
- Mathematical modeling reveals spontaneous emergence of self-replication in chemical reaction systems.The Journal of biological chemistry · 2018Article
- The Impact of Salts on Single Chain Amphiphile Membranes and Implications for the Location of the Origin of Life.Life (Basel, Switzerland) · 2017Review
- Generating minimal living systems from non-living materials and increasing their evolutionary abilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- The major synthetic evolutionary transitions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We review lessons learned about evolutionary transitions from a bottom-up construction of minimal life. We use a particular systemic protocell design process as a starting point for exploring two fundamental questions: (i) how may minimal living systems emerge from non-living materials? and (ii) how may minimal living systems support increasingly more evolutionary richness? Under (i), we present what has been accomplished so far and discuss the remaining open challenges and their possible solutions. Under (ii), we present a design principle we have used successfully both for our computational and experimental protocellular investigations, and we conjecture how this design principle can be extended for enhancing the evolutionary potential for a wide range of systems.This article is part of the themed issue 'The major synthetic evolutionary transitions'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.