ArticleEnvironmental research2016
Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1.
Article in Environmental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Pediatric kidney health outcomes in communities impacted by chronic kidney disease of unknown etiology (CKDu): a systematic review.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Fluoride Exposure in Community Prevention Programmes for Oral Health Using Nail Clippings and Spot Urine Samples: A Systematic Review and Meta-Analysis.Caries research · 2023Pooled it
- Toxic Metals and Chronic Kidney Disease: a Systematic Review of Recent Literature.Current environmental health reports · 2018Pooled it
- Potential Co-exposure to Arsenic and Fluoride and Biomonitoring Equivalents for Mexican Children.Annals of global health · 2018Pooled it
- Urinary KIM-1: a novel biomarker for evaluation of occupational exposure to lead.Scientific reports · 2016Trial
- Paediatric chronic kidney disease of unknown aetiology: early-life origins, detection, and prevention.Pediatric nephrology (Berlin, Germany) · 2026Review
- Environmental exposures and pediatric kidney health.Pediatric research · 2026Review
- Uncovering potential biomarkers for chronic kidney disease of unknown etiology through a network-based bioinformatic approach.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Clinical Profiles and Mortality-Associated Risk Factors in Patients with Acute Kidney Injury from Atlixco, Puebla, Mexico.Diagnostics (Basel, Switzerland) · 2025Article
- Vanadium exposure and kidney markers in a pediatric population: a cross-sectional study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Uranium exposure and kidney tubule biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).Environmental research · 2025Article
- Article
- Prenatal metal exposures and kidney function in adolescence in Project Viva.Environmental health : a global access science source · 2024Article
- Metal concentrations and KIM-1 levels in school-aged children: a cross-sectional study.Scientific reports · 2024Article
- Associations among environmental exposure to trace elements and biomarkers of early kidney damage in the pediatric population.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Systematic Review of Kidney Injury Biomarkers for the Evaluation of CKD of Uncertain Etiology.Kidney international reports · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Relationship between urinary biomarkers of early kidney damage and exposure to inorganic toxins in a pediatric population of Apizaco, Tlaxcala, Mexico.Journal of nephrology · 2023Article
- Epidemiological research progress in the effects of metal exposure on kidney.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment.Cell biology and toxicology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Environmental hazards from natural or anthropological sources are widespread, especially in the north-central region of Mexico. Children represent a susceptible population due to their unique routes of exposure and special vulnerabilities. In this study we evaluated the association of exposure to environmental kidney toxicants with kidney injury biomarkers in children living in San Luis Potosi (SLP), Mexico. A cross-sectional study was conducted with 83 children (5-12 years of age) residents of Villa de Reyes, SLP. Exposure to arsenic, cadmium, chromium, fluoride and lead was assessed in urine, blood and drinking water samples. Almost all tap and well water samples had levels of arsenic (81.5%) and fluoride (100%) above the permissible levels recommended by the World Health Organization. Mean urine arsenic (45.6ppb) and chromium (61.7ppb) were higher than the biological exposure index, a reference value in occupational settings. Using multivariate adjusted models, we found a dose-dependent association between kidney injury molecule-1 (KIM-1) across chromium exposure tertiles [(T1: reference, T2: 467pg/mL; T3: 615pg/mL) (p-trend=0.001)]. Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/μl) and miR-423 (189 copies/μL). Arsenic upper tertile was also associated with higher urinary KIM-1 (372pg/mL). Other kidney injury/functional biomarkers such as serum creatinine, glomerular filtration rate, albuminuria, neutrophil gelatinase-associated lipocalin and miR-21 did not show any association with arsenic, chromium or any of the other toxicants evaluated. We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.