ReviewJournal of optometry
The potential role of neuropathic mechanisms in dry eye syndromes.
Review in Journal of optometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- The Efficacy and Safety of Qiming Granule for Dry Eye Disease: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2020Pooled it
- Phosphosulindac (OXT-328) restores the suppressed corneal sensitivity in rabbits with dry eye disease: therapeutic implications.Frontiers in drug delivery · 2026Article
- Tear Film Alterations in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Are we treating the right dry eye? A comparative analysis of digital eye strain and traditional dry eye disease: a prospective comparative study.BMC ophthalmology · 2025Article
- The Relationship Between Anxiety Sensitivity, Emotional States, and Dry Eye Disease Symptom Severity: A Cross-Sectional Study.Vision (Basel, Switzerland) · 2025Article
- Glaucoma prevalence and treatment in sub-Saharan Africa's elderly population: a scoping review.BMC geriatrics · 2025Article
- Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis.Investigative ophthalmology & visual science · 2025Article
- A new R,R-RvD6 isomer with protective actions following corneal nerve injury.Prostaglandins & other lipid mediators · 2024Review
- Relationship between clinical parameters and quality of life in primary Sjögren's Syndrome: a prospective study.Eye (London, England) · 2023Article
- Successful reversal of neuropathic eye pain by treatment of occult ocular surface disease: Case series and implications.American journal of ophthalmology case reports · 2022Article
- Association of Dry Eye Diseases and Auditory Sensitivity.Journal of clinical medicine · 2022Article
- Gastrointestinal microbiome and primary Sjögren's syndrome: a review of the literature and conclusions.International journal of ophthalmology · 2022Review
- New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease.Journal of clinical medicine · 2021Review
- Corneal Nerve Abnormalities in Painful Dry Eye Disease Patients.Biomedicines · 2021Article
- Neuropathic Pain in the Eyes, Body, and Mouth: Insights from the Sjögren's International Collaborative Clinical Alliance.Pain practice : the official journal of World Institute of Pain · 2021Article
- Electroacupuncture Alleviates Inflammation of Dry Eye Diseases by Regulating theOxidative medicine and cellular longevity · 2021Article
- Clinical characteristics of dry eye with ocular neuropathic pain features: comparison according to the types of sensitization based on the Ocular Pain Assessment Survey.BMC ophthalmology · 2020Article
- Connections between intrinsically photosensitive retinal ganglion cells and TBI symptoms.Neurology · 2020Review
- Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease.Journal of autoimmunity · 2020Article
- Autoimmune Dry Eye without Significant Ocular Surface Co-Morbidities and Mental Health.Vision (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dry eye syndromes can involve both nociceptive and neuropathic symptoms. Nociceptive symptoms are the normal physiological responses to noxious stimuli. Neuropathic symptoms are caused by a lesion or disease of the somatosensory nervous system and can be the result of hypersensitisation of peripheral or central corneal and conjunctival somatosensory nerves. For example, inflammation could induce neuroplastic peripheral sensitisation of the ocular surface or lid wiper and exacerbate nociceptive symptoms. Neuropathic symptoms may explain the incommensurate relation between signs and symptoms in some dry eye syndromes although absence of signs of a dry eye syndrome may also be a consequence of inappropriate methods used when examining for them. Involvement of neuropathic mechanisms may also help explain dry eye symptoms which occur in association with reduced corneal sensitivity. This review includes a discussion of the potential for ocular symptoms involving neuropathic mechanisms to contribute to psychosocial problems such as depression, stress, anxiety and sleep disorders as well as for these types of psychosocial problems to contribute to neuropathic mechanisms and dry eye syndromes. Failure to consider the possibility that neuropathic mechanisms can contribute to dry eye syndromes may reduce accuracy of diagnosis and the suitability of treatment provided. Dry eye symptoms in the absence of commensurate evidence of tear dysfunction, and unsatisfactory response to tear dysfunction therapies should prompt consideration of neuropathic mechanisms being involved. Symptoms which persist after local anaesthetic instillation are more likely to be neuropathic in origin. Reducing inflammation may help limit any associated neuroplastic hypersensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.