ArticleCardiovascular diabetology2016
Clinical outcomes of deferred revascularisation using fractional flow reserve in patients with and without diabetes mellitus.
Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Long-term outcomes of patients with normal fractional flow reserve and thin-cap fibroatheroma.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Trial
- Plaque volume and plaque risk profile in diabetic vs. non-diabetic patients undergoing lipid-lowering therapy: a study based on 3D intravascular ultrasound and virtual histology.Cardiovascular diabetology · 2017Trial
- Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study.Cardiovascular diabetology · 2017Trial
- Prognostic implications of functional significance, high-risk plaque and vessel characteristics in patients with diabetes mellitus.The Korean journal of internal medicine · 2026Article
- Beyond borderline physiology: determinants of treatment choice and phenotypes of outcome in QFR grey-zone lesions.Cardiovascular diagnosis and therapy · 2026Article
- The safety profile of deferred revascularization in patients with coronary artery disease undergoing non-hyperemic functional assessments.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- Impact of Systematic Use of Fractional Flow Reserve and Optical Coherence Tomography on Percutaneous Coronary Intervention Outcomes in Patients With Diabetes.Cardiology research · 2025Article
- Cardiovascular Imaging for Coronary Artery Disease in Patients with Diabetes Mellitus.Journal of clinical medicine · 2024Review
- Deferred revascularization in diabetic patient according to combined invasive functional and intravascular imaging data: A case report.World journal of clinical cases · 2024Article
- Medically Treated Nonischemic Thin-Cap Fibroatheroma Lesions Versus Fractional Flow Reserve-Guided Complete Revascularization in Diabetic Patients.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Exploring new insights in coronary lesion assessment and treatment in patients with diabetes mellitus: the impact of optical coherence tomography.Cardiovascular diabetology · 2023Review
- Morphologies and composition changes in nonculprit subclinical atherosclerosis in diabetic versus nondiabetic patients with acute coronary syndrome who underwent long-term statin therapy.Scientific reports · 2023Observational
- Identification of vulnerable non-culprit lesions by coronary computed tomography angiography in patients with chronic coronary syndrome and diabetes mellitus.Frontiers in cardiovascular medicine · 2023Article
- Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation.Cardiovascular diabetology · 2022Article
- Impact of malondialdehyde-modified low-density lipoprotein on clinical outcomes after fractional flow reserve-guided deferral of revascularization.Heart and vessels · 2021Article
- Long-term outcome after deferred revascularization due to negative fractional flow reserve in intermediate coronary lesions.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2021Article
- Usefulness of Routine Fractional Flow Reserve for Clinical Management of Coronary Artery Disease in Patients With Diabetes.JAMA cardiology · 2020Article
- Searching for optimal blood pressure targets in type 2 diabetic patients with coronary artery disease.Cardiovascular diabetology · 2019Review
- Impact of type 2 diabetes mellitus on short- and long-term mortality after coronary artery bypass surgery.Cardiovascular diabetology · 2018Observational
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDeferred revascularisation based upon fractional flow reserve (FFR >0.80) is associated with a low incidence of target lesion failure (TLF). Whether deferred revascularisation is also as safe in diabetes mellitus (DM) patients is unknown.
methodsAll DM patients and the next consecutive Non-DM patients who underwent a FFR-assessment between 1/01/2010 and 31/12/2013 were included, and followed until 1/07/2015. Patients with lesions FFR >0.80 were analysed according to the presence vs. absence of DM, while patients who underwent index revascularisation in FFR-assessed or other lesions were excluded. The primary endpoint was the incidence of TLF; a composite of target lesion revascularisation (TLR) and target vessel myocardial infarction (TVMI).
resultsA total of 250 patients (122 DM, 128 non-DM) who underwent deferred revascularisation of all lesions (FFR >0.80) were compared. At a mean follow up of 39.8 ± 16.3 months, DM patients compared to non-DM had a higher TLF rate, 18.1 vs 7.5 %, logrank p ≤ 0.01, Cox regression-adjusted HR 3.65 (95 % CI 1.40-9.53, p < 0.01), which was largely driven by a higher incidence of TLR (17.2 vs. 7.5 %, HR 3.52, 95 % CI 1.34-9.30, p = 0.01), whilst a non-significant but numerically higher incidence of TVMI (6.1 vs. 2.0 %, HR 3.34, 95 % CI 0.64-17.30, p = 0.15) was observed.
conclusionsThis study, the largest to directly compare the clinical outcomes of FFR-guided deferred revascularisation in patients with and without DM, shows that DM patients are associated with a significantly higher TLF rate. Whether intravascular imaging, additional invasive haemodynamics or stringent risk factor modification may impact on this higher TLF rate remains unknown.
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