ReviewNature reviews. Urology2016
The prognostic role of lymphovascular invasion in urothelial carcinoma of the bladder.
Review in Nature reviews. Urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Blood-Based Biomarkers as Prognostic Factors of Recurrent Disease after Radical Cystectomy: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- A systematic review and meta-analysis of the impact of lymphovascular invasion in bladder cancer transurethral resection specimens.BJU international · 2019Pooled it
- SurvGRN: a multi-feature fusion framework for bladder cancer survival prediction.International journal of surgery (London, England) · 2026Article
- Clinical and pathological predictors of early recurrence after neoadjuvant cisplatin gemcitabine in muscle invasive bladder cancer in the RealBLADDER study.Scientific reports · 2026Observational
- MRI-based deep learning combined with radiomics for the preoperative prediction of lymphovascular invasion in patients with bladder cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- The added value of intratumoral and peritumoral radiomic scores based on iodine density map for preoperative prediction of lymphovascular invasion in patients with gastric adenocarcinoma: a two-center study.Abdominal radiology (New York) · 2026Article
- Utilizing imaging features of preoperative gadoxetic acid-enhanced MRI for predicting lymphovascular invasion in colorectal cancer liver metastases and exploring its impact on survival.BMC medical imaging · 2026Article
- Preoperative C-reactive protein-to-albumin ratio as a prognostic marker of histopathological characteristics and survival outcomes following radical cystectomy.Frontiers in oncology · 2026Article
- An interpretable machine learning model based on CT imaging for predicting lymphovascular invasion and survival in bladder urothelial carcinoma: a multicenter study.BMC medical imaging · 2025Article
- The staging of re-TURB is crucial in predicting the response to BCG therapy in patients with T1 high-grade bladder cancer.Investigative and clinical urology · 2025Article
- Development and external validation of a FISH-clinical nomogram for predicting overall survival in bladder cancer patients after radical cystectomy.BMC cancer · 2025Article
- Evaluation of inflammatory markers in survival analysis of patients undergoing radical cystectomy using machine learning.World journal of urology · 2025Article
- Deep learning feature-based model for predicting lymphovascular invasion in urothelial carcinoma of bladder using CT images.Insights into imaging · 2025Article
- ASO Author Reflections: How to Efficiently and Accurately Predict the Lymphovascular Invasion Status of Muscle-Invasive Bladder Cancer?Annals of surgical oncology · 2025Article
- Deep Learning Predicts Lymphovascular Invasion Status in Muscle Invasive Bladder Cancer Histopathology.Annals of surgical oncology · 2025Article
- Article
- Clinicopathological characteristics, surgical treatments, and oncological outcomes of localized primary unifocal urothelial carcinoma involving the ureterovesical junction.International urology and nephrology · 2024Article
- Multi-omics analysis reveals critical metabolic regulators in bladder cancer.International urology and nephrology · 2024Article
- The Effect of Lymphovascular Invasion on Short-Term Tumor Recurrence and Progression in Stage T1 Bladder Cancer.Cureus · 2024Article
- Pan-immune-inflammation value as a prognostic tool for overall survival and disease-free survival in non-metastatic muscle-invasive bladder cancer.International urology and nephrology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Outcome prediction in patients with bladder cancer has improved through the development of nomograms and predictive models. However, integration of further characteristics such as lymphovascular invasion (LVI) might increase the accuracy and clinical utility of these instruments. Assessment and reporting of LVI in specimens from transurethral resection of the bladder tumour (TURBT) or biopsy in patients with non-muscle-invasive bladder cancer (NMIBC) or muscle-invasive bladder cancer (MIBC) might enable improved staging, prognostication and clinical decision-making. In NMIBC, presence of LVI in TURBT and biopsy samples seems to be associated with understaging and increased risks of disease recurrence and progression. In MIBC, presence of LVI is associated with features of aggressive disease and predicts recurrence and survival. Integration of LVI status into predictive models might aid clinical decision-making regarding intravesical instillation schedules and regimens, early radical cystectomy in patients with high-grade T1 disease and perioperative chemotherapy. However, LVI assessment is hampered by insufficient reproducibility and reliability, lack of routine evaluation and limited concordance between findings in TURBT and radical cystectomy specimens. Standardization of the pathological criteria defining LVI is warranted to improve its reporting in routine clinical practice and its utility as a care-changing prognostic marker.
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