ArticleHealth and quality of life outcomes2016
A comparison of health utility scores calculated using United Kingdom and Canadian preference weights in persons with alzheimer's disease and their caregivers.
Article in Health and quality of life outcomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Estimated disability weights for the severity of health outcomes: a systematic review and meta-analysis.Population health metrics · 2025Pooled it
- Spillover Effects on Caregivers' and Family Members' Utility: A Systematic Review of the Literature.PharmacoEconomics · 2019Pooled it
- The effectiveness and cost-effectiveness of assistive technology and telecare for independent living in dementia: a randomised controlled trial.Age and ageing · 2021Trial
- Eliciting national and subnational sets of disability weights in mainland China: Findings from the Chinese disability weight measurement study.The Lancet regional health. Western Pacific · 2022Article
- Quality of Life in Caregivers of Patients Randomized to Standard- Versus Extended-Hours Hemodialysis.Kidney international reports · 2021Article
- A cost-utility analysis of atezolizumab in the second-line treatment of patients with metastatic bladder cancer.Current oncology (Toronto, Ont.) · 2020Article
- Age- and sex-specific Canadian utility norms, based on the 2013-2014 Canadian Community Health Survey.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Disability weights for infectious diseases in four European countries: comparison between countries and across respondent characteristics.European journal of public health · 2018Article
- Estimates of health utility scores in chronic kidney disease.International urology and nephrology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of the EQ-5D to asses the economic benefits of health technologies has led to questions about the cross-population transferability of preference weights to calculate health utility scores. The aim of this study is to investigate whether the use of UK and Canadian preference weights will lead to the calculation of different health utility scores in a sample of persons with Alzheimer's disease (AD) and their primary informal caregivers.
methodsWe recruited 216 patient-caregiver dyads from nine geriatric and memory clinics across Canada. Participants used the EQ-5D-3L to rate their health-related quality-of-life (HRQoL). EQ-5D-3L responses were transformed into health utility scores using UK and Canadian preference weights. The levels of agreement between the two sets of scores were assessed using intraclass correlation coefficients (ICCs). Bland-Altman plots depicted individual-level differences between the two sets of scores. Differences in health utility scores were tested using the Wilcoxon signed rank sum test. A generalized linear model with a gamma distribution was used to examine whether participants' socio-demographic characteristics were associated with their health utility scores.
resultsThe distributions of health utility scores derived from both the UK and Canadian preference weights were skewed to the left. The intraclass correlation coefficient was 0.94 (95 % CI: 0.92, 0.95) for persons with AD and 0.92 (95 % CI: 0.88, 0.94) for the caregivers. The Canadian weights yielded slightly higher median health utility scores than the UK weights for caregivers (median difference: 0.009; 95 % confidence interval: 0.007, 0.013). This finding persisted after stratifying by disease severity. Few socio-demographic characteristics were associated with the two sets of health utility scores.
conclusionsHealth utility scores exhibited small and clinically unimportant differences when calculated with UK versus Canadian preference weights in persons with AD and their caregivers. The original UK and Canadian population samples used to obtain the preference weights valued health states similarly.
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