ArticleMolecular psychiatry2017
Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.Translational psychiatry · 2017Pooled it
- A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort.Translational psychiatry · 2017Trial
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- Integration of whole-exome sequencing and structural neuroimaging analysis in major depressive disorder: a joint study.Translational psychiatry · 2024Article
- Common and rare variant associations with latent traits underlying depression, bipolar disorder, and schizophrenia.Translational psychiatry · 2023Article
- Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants.HGG advances · 2023Article
- Targeted sequencing of the BDNF gene in young Chinese Han people with major depressive disorder.Molecular genetics & genomic medicine · 2020Article
- Missing heritability in Parkinson's disease: the emerging role of non-coding genetic variation.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population.Neuropsychiatric disease and treatment · 2020Article
- Exome Sequencing Analysis Identifies Rare Variants inFrontiers in genetics · 2020Article
- Association of plasma endothelial lipase levels on cognitive impairment.BMC psychiatry · 2019Article
- [Breakthrough in understanding the molecular causes of psychiatric disorders].Der Nervenarzt · 2019Review
- Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms.Neuropsychiatric disease and treatment · 2019Article
- Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder.Translational psychiatry · 2018Article
- Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness.Frontiers in genetics · 2018Article
- Progress in Genetic Studies of Tourette's Syndrome.Brain sciences · 2017Review
- Exome-Wide Meta-Analysis Identifies Rare 3'-UTR Variant in ERCC1/CD3EAP Associated with Symptoms of Sleep Apnea.Frontiers in genetics · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
26 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite a substantial genetic component, efforts to identify common genetic variation underlying depression have largely been unsuccessful. In the current study we aimed to identify rare genetic variants that might have large effects on depression in the general population. Using high-coverage exome-sequencing, we studied the exonic variants in 1265 individuals from the Rotterdam study (RS), who were assessed for depressive symptoms. We identified a missense Asn396Ser mutation (rs77960347) in the endothelial lipase (LIPG) gene, occurring with an allele frequency of 1% in the general population, which was significantly associated with depressive symptoms (P-value=5.2 × 10
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