ArticleAntimicrobial agents and chemotherapy2016
Bacterial Spheroplasts as a Model for Visualizing Membrane Translocation of Antimicrobial Peptides.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Membrane-Traversing Peptides: Mechanistic Landscapes, Assays, and Applications.Chemical reviews · 2026Review
- DesHDAP2 Shows Significant Synergy with Conventional Antibiotics, Despite Its Relatively Low Potency.ACS omega · 2025Article
- Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization.ACS medicinal chemistry letters · 2024Article
- Solanum lycopersicum heme-binding protein 2 as a potent antimicrobial weapon against plant pathogens.Scientific reports · 2023Article
- Monomer and Oligomer Transition of Zinc Phthalocyanine Is Key for Photobleaching in Photodynamic Therapy.Molecules (Basel, Switzerland) · 2023Article
- Effect of membrane potential on entry of lactoferricin B-derived 6-residue antimicrobial peptide into singleJournal of bacteriology · 2021Article
- Are Bacterial Persisters Dormant Cells Only?Frontiers in microbiology · 2021Review
- Antimicrobial Mechanism of pBD2 againstMolecules (Basel, Switzerland) · 2020Article
- A Potent Host Defense Peptide Triggers DNA Damage and Is Active against Multidrug-Resistant Gram-Negative Pathogens.ACS infectious diseases · 2020Article
- Action of antimicrobial peptides and cell-penetrating peptides on membrane potential revealed by the single GUV method.Biophysical reviews · 2020Review
- Hybrids made from antimicrobial peptides with different mechanisms of action show enhanced membrane permeabilization.Biochimica et biophysica acta. Biomembranes · 2019Article
- Using fluorescence microscopy to shed light on the mechanisms of antimicrobial peptides.Future medicinal chemistry · 2019Review
- Membrane potential is vital for rapid permeabilization of plasma membranes and lipid bilayers by the antimicrobial peptide lactoferricin B.The Journal of biological chemistry · 2019Article
- Analysis of the antimicrobial mechanism of porcine beta defensin 2 against E. coli by electron microscopy and differentially expressed genes.Scientific reports · 2018Article
- Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization.Journal of visualized experiments : JoVE · 2018Article
- Investigating the nucleic acid interactions of histone-derived antimicrobial peptides.FEBS letters · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Studies attempting to characterize the membrane translocation of antimicrobial and cell-penetrating peptides are frequently limited by the resolution of conventional light microscopy. This study shows that spheroplasts provide a valuable approach to overcome these limits. Spheroplasts produce less ambiguous images and allow for more systematic analyses of localization. Data collected with spheroplasts are consistent with studies using normal bacterial cells and imply that a particular peptide may not always follow the same mechanism of action.
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Registered trials
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