Evidence map›Paper›PMID 27430736›Full record

ArticleBMC family practice2016

Towards improving diagnosis of memory loss in general practice: TIMeLi diagnostic test accuracy study protocol.

Sam T Creavin, Sarah J Cullum, Judy Haworth, Lesley Wye, Antony Bayer, Mark Fish, Sarah Purdy, Yoav Ben-Shlomo

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in BMC family practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Cognitive tests to help diagnose dementia in symptomatic people in primary care and the community.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sam T CreavinSchool of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, BS8 2PS, UK. Sam.Creavin@bristol.ac.uk.
Sarah J CullumSchool of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, BS8 2PS, UK.
Judy HaworthNorth Bristol NHS Trust Southmead Hospital, Southmead Road, Westbury-on-Trym, Bristol, BS10 5NB, UK.
Lesley WyeSchool of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, BS8 2PS, UK.
Antony BayerDivision of Population Medicine, Cardiff University School of Medicine University Hospital Llandough, Penarth, CF64 2XX, UK.
Mark FishDepartment of Neurology, Musgrove Park Hospital, Taunton, Somerset, TA1 5DA, UK.
Sarah PurdySchool of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, BS8 2PS, UK.
Yoav Ben-ShlomoSchool of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, BS8 2PS, UK.
University of Bristol · GBCardiff University · GBMusgrove Park Hospital · GBNorth Bristol NHS Trust · GB

Funding

Wellcome TrustWellcome Trust 108804/Z/15/Z
6 · The paper itself

Abstract

backgroundPeople with cognitive problems, and their families, report distress and uncertainty whilst undergoing evaluation for dementia and perceive that traditional diagnostic evaluation in secondary care is insufficiently patient centred. The James Lind Alliance has prioritised research to investigate the role of primary care in supporting a more effective diagnostic pathway, and the topic is also of interest to health commissioners. However, there are very few studies that investigate the accuracy of diagnostic tests for dementia in primary care.

methodsWe will conduct a prospective diagnostic test accuracy study to evaluate the accuracy of a range of simple tests for diagnosing all-cause-dementia in symptomatic people aged over 70 years who have consulted with their general practitioner (GP). We will invite eligible people to attend a research clinic where they will undergo a range of index tests that a GP could perform in the surgery and also be assessed by a specialist in memory disorders at the same appointment. Participating GPs will request neuroimaging and blood tests and otherwise manage patients in line with their usual clinical practice. The reference standard will be the consensus judgement of three experts (neurologist, psychiatrist and geriatrician) based on information from the specialist assessment, GP records and investigations, but not including items in the index test battery. The target condition will be all-cause dementia but we will also investigate diagnostic accuracy for sub-types where possible. We will use qualitative interviews with patients and focus groups with clinicians to help us understand the acceptability and feasibility of diagnosing dementia in primary care using the tests that we are investigating. DISCUSSION: Our results will help clinicians decide on which tests to perform in someone where there is concern about possible dementia and inform commissioning of diagnostic pathways.

Indexed as

AgedCognitive DysfunctionDementiaExercise TestFocus GroupsGeneral PracticeHumansInterviews as TopicMagnetic Resonance ImagingMemory DisordersNeuroimagingNeuropsychological TestsProspective StudiesReproducibility of ResultsResearch DesignSingle Photon Emission Computed Tomography Computed TomographyDementiaDiagnostic testsGeneral practicePrimary careSensitivity and specificity

Identifiers

PMID27430736
PMCPMC4950265
OpenAlexW2485570974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.