ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2017
Nausea in Children With Functional Abdominal Pain Predicts Poor Health Outcomes in Young Adulthood.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Identifying Prognostic Factors Implicated in Chronic Functional Abdominal Pain in Children: A Systematic Review.Gastroenterology research · 2026Review
- Article
- Noninvasive Quantification of Nausea Severity in Pediatric Functional Nausea.Gastro hep advances · 2025Article
- Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- A therapeutic guide on pediatric irritable bowel syndrome and functional abdominal pain-not otherwise specified.European journal of pediatrics · 2022Review
- Sex Moderates the Relationship Between Nausea Severity and Heart Rate Variability in Adolescents and Young Adults.Digestive diseases and sciences · 2022Article
- The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children.Neurogastroenterology and motility · 2021Article
- An Update on the Assessment and Management of Pediatric Abdominal Pain.Pediatric health, medicine and therapeutics · 2021Review
- Development and validation of the paediatric Carbohydrate Perception Questionnaire (pCPQ), an instrument for the assessment of carbohydrate-induced gastrointestinal symptoms in the paediatric population.Neurogastroenterology and motility · 2020Article
- "My Body Hates Me": A Qualitative Analysis of the Experience of Functional Nausea in Adolescent Girls and Their Mothers.Children (Basel, Switzerland) · 2020Article
- A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning.BMC gastroenterology · 2020Article
- The Effects of the Rome IV Criteria on Pediatric Gastrointestinal Practice.Current gastroenterology reports · 2020Review
- Development and Validation of a Nausea Severity Scale for Assessment of Nausea in Children with Abdominal Pain-Related Functional Gastrointestinal Disorders.Children (Basel, Switzerland) · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsNausea is common among children with functional abdominal pain (FAP). We evaluated the relation of nausea to short- and long-term morbidity in pediatric patients with FAP.
methodsWe performed a prospective study of 871 children with FAP (age, 8-17 y) seen in a pediatric gastroenterology practice; follow-up data were collected from 392 of the patients at 8.7 ± 3.3 years later. Participants were defined as having significant nausea if they reported nausea "a lot" or "a whole lot" within the past 2 weeks. Validated questionnaires assessed abdominal pain, gastrointestinal and somatic symptoms, and depression. Baseline measures, anxiety, and the Rome III criteria were assessed in the follow-up evaluation.
resultsAt baseline, 44.8% of the patients reported significant nausea. Those with nausea reported worse abdominal pain, gastrointestinal symptoms, somatic symptoms, and depression than those without nausea (P < .001 for all). When the children had reached young adulthood, those with nausea in childhood continued to have more severe gastrointestinal (P < .001) and somatic symptoms (P = .003) than patients without nausea in childhood, as well as higher levels of anxiety (P = .02) and depression (P = .02). In the follow-up evaluation, somatic symptoms, depression, and anxiety remained significant after controlling for baseline abdominal pain severity.
conclusionsPediatric patients with FAP and nausea have more severe short- and long-term gastrointestinal and somatic symptoms than patients with FAP without nausea, as well as reductions in mental health and daily function. Pediatric patients with FAP and nausea therefore need intensive treatment and follow-up evaluation.
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