ArticleThe Journal of allergy and clinical immunology2016
Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 55 citations in OpenAlex.
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- Cat exposure and asthma outcomes in a cohort of children with asthma and allergy.Frontiers in allergy · 2026Article
- Furry Animal Allergy: Lipocalins, Serum Albumins, and Secretoglobins-Cross-Reactivity, Diagnosis, and Management Strategies.Clinical reviews in allergy & immunology · 2025Review
- The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat.Immunological reviews · 2025Review
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- Isotype diversity of antibodies specific for component allergens in the context of allergic diseases: eosinophilic esophagitis (EoE), asthma, and the alpha-gal syndrome (AGS).Frontiers in allergy · 2024Review
- Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017.The journal of allergy and clinical immunology. Global · 2023Article
- Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander.Clinical and translational allergy · 2023Article
- Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Article
- Allergic sensitization pattern as a marker of bronchial hyperresponsiveness in allergic rhinitis patients living in temperate continental climate zone.Wiener klinische Wochenschrift · 2022Article
- Environmental Exposures Impact Pediatric Asthma Within the School Environment.Immunology and allergy clinics of North America · 2022Review
- Allergic sensitization to lipocalins reflects asthma morbidity in dog dander sensitized children.Clinical and translational allergy · 2022Article
- Cat allergen exposure in a naturalistic exposure chamber: A prospective observational study in cat-allergic subjects.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Observational
- Aspergillus sensitization associated with current asthma in children in the United States: an analysis of data from the 2005-2006 NHANES.Epidemiology and health · 2022Article
- α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgGThe Journal of allergy and clinical immunology · 2021Article
- The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic.Microorganisms · 2021Article
- A dynamic relationship between two regional causes of IgE-mediated anaphylaxis: α-Gal syndrome and imported fire ant.The Journal of allergy and clinical immunology · 2021Article
- Inhalant Mammal-Derived Lipocalin Allergens and the Innate Immunity.Frontiers in allergy · 2021Review
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8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAlthough sensitization to indoor allergens is strongly associated with asthma, there are questions as to how this relates to asthma symptoms.
objectiveWe sought to study the relevance of IgE antibodies to cat and dog allergens in an area in which (1) the climate discourages cockroach, fungal, and mite growth and (2) dander allergens are known to be present in schools and houses without animals.
methodsIgE to 8 allergens was tested in 963 sera from a population-based study on 19-year-olds, and associations with asthma symptoms, diagnosis, and treatment were examined. In positive sera IgE to specific cat and dog allergens was also assayed.
resultsIgE specific for animal dander had the highest prevalence and strongest relationship to asthma diagnosis. Furthermore, asthma severity, as judged by the frequency of symptoms and use of treatment, was directly associated with the titer of IgE antibodies to animal dander. Among the 103 subjects who had current asthma at age 19 years, 50 had asthma before age 12 years. Among those 50, the odds ratios for asthma related to any IgE antibodies to animal dander or high-titer IgE antibodies (≥17.5 IU/mL) were 9.2 (95% CI, 4.9-17) and 13 (95% CI, 6.9-25), respectively. In multivariable analysis IgE antibodies to Fel d 1 and Can f 5 were each associated with current asthma.
conclusionHigh-titer IgE antibodies to cat and dog allergens were strongly associated with the diagnosis, severity, and persistence of asthma; however, a large proportion of patients with current asthma did not live in a house with a cat or dog.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.