ArticleThe American journal of tropical medicine and hygiene2016
Plasmodium falciparum Drug-Resistant Haplotypes and Population Structure in Postearthquake Haiti, 2010.
Article in The American journal of tropical medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Assessment of Plasmodium falciparum anti-malarial drug resistance markers in pfcrt and pfmdr1 genes in isolates from Honduras and Nicaragua, 2018-2021.Malaria journal · 2021Article
- Bias-corrected maximum-likelihood estimation of multiplicity of infection and lineage frequencies.PloS one · 2021Article
- Investigations of socioeconomic factors associated with follow-up compliance with malaria treatment in Haiti.Revista panamericana de salud publica = Pan American journal of public health · 2021Article
- Establishing a National Molecular Surveillance Program for the Detection ofThe American journal of tropical medicine and hygiene · 2020Article
- Genetic analysis reveals unique characteristics of Plasmodium falciparum parasite populations in Haiti.Malaria journal · 2020Article
- Nationwide Monitoring for Plasmodium falciparum Drug-Resistance Alleles to Chloroquine, Sulfadoxine, and Pyrimethamine, Haiti, 2016-2017.Emerging infectious diseases · 2020Article
- Trends in Molecular Markers Associated with Resistance to Sulfadoxine-Pyrimethamine (SP) AmongInfection and drug resistance · 2020Article
- No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti.Emerging infectious diseases · 2018Article
- Malaria Surveillance - United States, 2015.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2018Article
- Haiti's Commitment to Malaria Elimination: Progress in the Face of Challenges, 2010-2016.The American journal of tropical medicine and hygiene · 2017Article
- Molecular Characterization of a Cluster of Imported Malaria Cases in Puerto Rico.The American journal of tropical medicine and hygiene · 2017Article
- Malaria Surveillance - United States, 2014.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2017Article
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Authors and funding
13 authors.
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Abstract
Chloroquine (CQ) remains the first-line treatment of malaria in Haiti. Given the challenges of conducting in vivo drug efficacy trials in low-endemic settings like Haiti, molecular surveillance for drug resistance markers is a reasonable approach for detecting resistant parasites. In this study, 349 blood spots were collected from suspected malaria cases in areas in and around Port-au-Prince from March to July 2010. Among them, 121 samples that were Plasmodium falciparum positive by polymerase chain reaction were genotyped for drug-resistant pfcrt, pfdhfr, pfdhps, and pfmdr1 alleles. Among the 108 samples that were successfully sequenced for CQ resistant markers in pfcrt, 107 were wild type (CVMNK), whereas one sample carried a CQ-resistant allele (CVIET). Neutral microsatellite genotyping revealed that the CQ-resistant isolate was distinct from all other samples in this study. Furthermore, the remaining parasite specimens appeared to be genetically distinct from other reported Central and South American populations.
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