Evidence map›Paper›PMID 27430527›Full record

ArticleImmunology and cell biology2017

Stat3 and C/EBPβ synergize to induce miR-21 and miR-181b expression during sepsis.

Clara McClure, Melissa B McPeak, Dima Youssef, Zhi Q Yao, Charles E McCall, Mohamed El Gazzar

Abstract read
In one paragraph

Article in Immunology and cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. MicroRNA Profiles in Critically Ill Patients.Current medicinal chemistry · 2024
    Review
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  9. Review
  10. C/EBPβ enhances immunosuppression activity of myeloid-derived suppressor cells by a P300-mediated acetylation modification.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
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  13. Article
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  19. Article
  20. Hypomethylation CausesMolecular therapy oncolytics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Clara McClureDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, USA.
Melissa B McPeakDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, USA.
Dima YoussefDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, USA.
Zhi Q YaoDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, USA.
Charles E McCallDepartment of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Mohamed El GazzarDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, USA.
East Tennessee State University · USWake Forest University · US

Funding

MicroRNAs and myeloid cell development during sepsisR01GM103887 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI ELGAZZAR, MOHAMED A. · 2013 to 2018
$1.4M
NIGMS NIH HHS R01 GM103887
6 · The paper itself

Abstract

Myeloid-derived suppressor cells (MDSCs) increase late sepsis immunosuppression and mortality in mice. We reported that microRNA (miR) 21 and miR-181b expression in Gr1

Indexed as

Gene Expression RegulationAnimalsAntigens, CDBinding SitesCCAAT-Enhancer-Binding Protein-betaElectrophoretic Mobility Shift AssayGene Knockdown TechniquesGenes, ReporterMaleMice, Inbred BALB CMicroRNAsModels, BiologicalMyeloid-Derived Suppressor CellsPhosphorylationPromoter Regions, GeneticProtein BindingAntigens, CDCCAAT-Enhancer-Binding Protein-betaMicroRNAsmirn181 microRNA, mouseMIRN21 microRNA, mouseRetinoblastoma ProteinSTAT3 Transcription Factor

Identifiers

PMID27430527
PMCPMC5209283
OpenAlexW2499003778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.