Evidence map›Paper›PMID 27430454›Full record

ReviewHandbook of clinical neurology2016

Neuroimaging of epilepsy.

Fernando Cendes, William H Theodore, Benjamin H Brinkmann, Vlastimil Sulc, Gregory D Cascino

Open access · greenAbstract readReview
In one paragraph

Review in Handbook of clinical neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 3 pooled it
46.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 167 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. ILAE neuroimaging task force highlight: MRI detection of early life epilepsy caused by focal cortical dysplasia.Epileptic disorders : international epilepsy journal with videotape · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  18. Review
  19. Article
  20. Neuropsychiatric disease and treatment · 2024
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Fernando CendesUniversity of Campinas, Department of Neurology, Campinas, SP, Brazil.
William H TheodoreNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Benjamin H BrinkmannDivision of Epilepsy, Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Vlastimil SulcDepartment of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Czech Republic.
Gregory D CascinoDivision of Epilepsy, Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic · USCharles University · CZNational Institute of Neurological Disorders and Stroke · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Physiologic And Pharmacologic Studies In EpilepsyZIANS002236 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI THEODORE, WILLIAM · 2009 to 2020
$14.2M
PHYSIOLOGIC AND PHARMACOLOGIC STUDIES IN EPILEPSYZ01NS002236 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI THEODORE, WILLIAM H · 1985 to 2008
$1.1M
Intramural NIH HHS Z01 NS002236
6 · The paper itself

Abstract

Imaging is pivotal in the evaluation and management of patients with seizure disorders. Elegant structural neuroimaging with magnetic resonance imaging (MRI) may assist in determining the etiology of focal epilepsy and demonstrating the anatomical changes associated with seizure activity. The high diagnostic yield of MRI to identify the common pathological findings in individuals with focal seizures including mesial temporal sclerosis, vascular anomalies, low-grade glial neoplasms and malformations of cortical development has been demonstrated. Positron emission tomography (PET) is the most commonly performed interictal functional neuroimaging technique that may reveal a focal hypometabolic region concordant with seizure onset. Single photon emission computed tomography (SPECT) studies may assist performance of ictal neuroimaging in patients with pharmacoresistant focal epilepsy being considered for neurosurgical treatment. This chapter highlights neuroimaging developments and innovations, and provides a comprehensive overview of the imaging strategies used to improve the care and management of people with epilepsy.

Indexed as

NeuroimagingElectroencephalographyEpilepsyHumansImage Processing, Computer-Assisted18F-fluorodeoxyglucose–positron emission tomography (18F-FDG-PET)computed tomography (CT)drug-resistant focal epilepsyEpilepsyictal single photon emission computed tomography (SPECT)magnetic resonance imaging (MRI)surgical treatment of epilepsy

Identifiers

PMID27430454
PMCPMC5256664
OpenAlexW2483342487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.