ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2016
Sequential dietary exposure to aflatoxin B1 and fumonisin B1 in F344 rats increases liver preneoplastic changes indicative of a synergistic interaction.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 68 citations in OpenAlex.
- Pollution characteristics, enrichment patterns, and progress in detoxification research of mycotoxins in maize.Mycotoxin research · 2026Review
- Integrated Proteomic and Metabolomic Profiling of the Secretome ofJournal of fungi (Basel, Switzerland) · 2025Article
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- Liver Lipidomics, Histology, Transcriptomics, and Clinical Chemistry of Rats Intraperitoneally Treated with Fumonisin B1 for 5 days.Journal of agricultural and food chemistry · 2025Article
- Effect of oral administration ofOpen veterinary journal · 2025Article
- Aflatoxin B1-Induced Apoptosis in Donkey Kidney via EndoG-Mediated Endoplasmic Reticulum Stress.Veterinary sciences · 2025Article
- Effects of aflatoxin and fumonisin on gene expression of growth factors and inflammation-related genes in a human hepatocyte cell line.Mutagenesis · 2024Article
- Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China.Toxins · 2023Article
- The role of chromatin-modifying enzymes and histone modifications in the modulation of p16 gene in fumonisin BMycotoxin research · 2023Article
- Article
- Review
- The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats.International journal of molecular sciences · 2021Article
- Current Perspectives of Biocontrol Agents for Management ofJournal of fungi (Basel, Switzerland) · 2021Review
- QuEChERS LC-MS/MS Screening Method for Mycotoxin Detection in Cereal Products and Spices.International journal of environmental research and public health · 2021Article
- Evaluation of aflatoxin and fumonisin co-exposure in urine samples from healthy volunteers in northern Mexico.Toxicology reports · 2021Article
- Parallel validation of a green-solvent extraction method and quantitative estimation of multi-mycotoxins in staple cereals using LC-MS/MS.Scientific reports · 2020Article
- Aflatoxins: Producing-Molds, Structure, Health Issues and Incidence in Southeast Asian and Sub-Saharan African Countries.International journal of environmental research and public health · 2020Review
- Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China.BMC cancer · 2019Article
- Article
- Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies.Toxins · 2019Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Dietary co-exposure to aflatoxin B1 (AFB1) and fumonisin B1 (FB1) and their interaction on hepatocellular carcinogenesis is of particular concern in toxicology and public health. In this study we evaluated the liver preneoplastic effects of single and sequential dietary exposure to AFB1 and FB1 in the F344 rat carcinogenesis model. Serum biochemical alterations, liver histopathological changes, and the formation of liver glutathione S transferase positive (GST-P+) foci were the major outcome parameters examined. Compared to the AFB1-only treatment, the FB1-only treatment induced less dysplasia, and more apoptosis and mitoses. Sequential AFB1 and FB1 treatment lead to increased numbers of dysplasia, apoptosis and foci of altered hepatocytes, as compared to either mycotoxin treatment alone. More importantly, sequential exposure to AFB1 and FB1 synergistically increased the numbers of liver GTP-P+ foci by approximately 7.3-and 12.9-fold and increased the mean sizes of GST-P+ foci by 6- and 7.5-fold, respectively, as compared to AFB1- or FB1-only treatment groups. In addition, liver ALT and AST levels were significantly increased after sequential treatment as compared to single treatment groups. The results demonstrate the interactive effect of dietary AFB1 and FB1 in inducing liver GST-P+ foci formation and provide information to model future intervention studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.