ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2016
Default Mode Hypoconnectivity Underlies a Sex-Related Autism Spectrum.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.NeuroImage. Clinical · 2021Pooled it
- Sex Similarities and Differences in Brain Dynamic Functional Connectivity Among Individuals With and Without Autism Spectrum Disorders.Human brain mapping · 2025Article
- Perinatal Western-style diet exposure associated with altered sensory functional connectivity in infant Japanese macaques.Physiological reports · 2025Article
- Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds.Journal of neurodevelopmental disorders · 2025Article
- Effects of insecure attachment on fMRI resting state functional connectivity in poly drug use disorder.PloS one · 2025Observational
- Atypical Brain Connectivity During Pragmatic and Semantic Language Processing in Children with Autism.Brain sciences · 2024Article
- Differently different?: A commentary on the emerging social cognitive neuroscience of female autism.Biology of sex differences · 2024Review
- Perinatal Western-style diet exposure associated with decreased microglial counts throughout the arcuate nucleus of the hypothalamus in Japanese macaques.Journal of neurophysiology · 2024Article
- Giftedness and atypical sexual differentiation: enhanced perceptual functioning through estrogen deficiency instead of androgen excess.Frontiers in endocrinology · 2024Review
- Similar overall expression, but different profiles, of autistic traits, sensory processing, and mental health between young adult males and females.Research in autism spectrum disorders · 2023Article
- Conditional Variational Autoencoder for Functional Connectivity Analysis of Autism Spectrum Disorder Functional Magnetic Resonance Imaging Data: A Comparative Study.Bioengineering (Basel, Switzerland) · 2023Article
- The autism spectrum among transgender youth: default mode functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Identification of diagnostic markers for ASD: a restrictive interest analysis based on EEG combined with eye tracking.Frontiers in neuroscience · 2023Article
- Alterations in Social Brain Network Topology at Rest in Children With Autism Spectrum Disorder.Psychiatry investigation · 2022Article
- Sex differences in neuronal systems function and behaviour: beyond a single diagnosis in autism spectrum disorders.Translational psychiatry · 2021Review
- Neural-level associations of non-verbal pragmatic comprehension in young Finnish autistic adults.International journal of circumpolar health · 2021Article
- Towards robust and replicable sex differences in the intrinsic brain function of autism.Molecular autism · 2021Article
- Thalamocortical connectivity is associated with autism symptoms in high-functioning adults with autism and typically developing adults.Translational psychiatry · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
backgroundFemales and males differ significantly in the prevalence and presentation of autism spectrum conditions. One theory of this effect postulates that autistic traits lie on a sex-related continuum in the general population, and autism represents the extreme male end of this spectrum. This theory predicts that any feature of autism in males should 1) be present in autistic females, 2) differentiate between the sexes in the typical population, and 3) correlate with autistic traits. We tested these three predictions for default mode network (DMN) hypoconnectivity during the resting state, one of the most robustly found neurobiological differences in autism.
methodsWe analyzed a primary dataset of adolescents (
resultsWe found significant differences in DMN intraconnectivity between female controls and females with autism (
conclusionsCollectively, these findings provide the first evidence for DMN hypoconnectivity as a behaviorally relevant neuroimaging phenotype of the sex-related spectrum of autistic traits, of which autism represents the extreme case.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.