Evidence map›Paper›PMID 27430028›Full record

ArticleParasite epidemiology and control2016

Analysis of the population-level impact of co-administering ivermectin with albendazole or mebendazole for the control and elimination of

Hugo C Turner, James E Truscott, Alison A Bettis, T Déirdre Hollingsworth, Simon J Brooker, Roy M Anderson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasite epidemiology and control, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Supporting Drug Development for Neglected Tropical Diseases Using Mathematical Modeling.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  6. Parasitology · 2021
    Article
  7. Article
  8. Observational
  9. Efficacy of Albendazole-Pyrantel Pamoate Compared to Albendazole Alone forThe Malaysian journal of medical sciences : MJMS · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Investigating the Effectiveness of Current and Modified World Health Organization Guidelines for the Control of Soil-Transmitted Helminth Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Prospects for elimination of soil-transmitted helminths.Current opinion in infectious diseases · 2017
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hugo C TurnerLondon Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK; Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK.
James E TruscottLondon Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK; Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK.
Alison A BettisLondon Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK; Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK.
T Déirdre HollingsworthMathematics Institute, University of Warwick, Coventry CV4 7AL, UK; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.
Simon J BrookerFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Roy M AndersonLondon Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK; Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK.
Imperial College London · GBLondon Centre for Neglected Tropical Disease Research · GBLondon School of Hygiene & Tropical Medicine · GBUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSoil-transmitted helminth (STH) infections are predominately controlled by providing children with preventive chemotherapy with either albendazole or mebendazole. However, neither has a high efficacy against

methodsUsing a STH transmission mathematical model, we evaluated the potential impact of co-administering ivermectin with albendazole or mebendazole to treat

resultsAlthough the current treatment strategy reduced

conclusionsCo-administering ivermectin notably increased the projected impact of preventive chemotherapy in high transmission settings and increased the feasibility for breaking transmission. This has important implications for control programmes, some of which may be shifting focus from morbidity control to interruption of transmission, and some of which may be logistically unable to provide preventive chemotherapy twice a year as recommended. However, the benefit of co-administering ivermectin is limited by the fact that 2-5 year olds are often ineligible to receive treatment.

Indexed as

ALB, albendazoleControlEliminationERRs, egg reduction ratesIvermectin co-administrationIVM, ivermectinMass drug administrationMBZ, mebendazolePre-SAC, preschool-agedR0, basic reproductive numberSAC, school-aged childrenSoil-transmitted helminthSTH, soil-transmitted helminthTrichuris trichiuraWASH, water, sanitation and hygieneWHO, World Health Organisation

Identifiers

PMID27430028
PMCPMC4946157
OpenAlexW2332412585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.