ArticleJournal of clinical movement disorders2016
Depressive symptoms can amplify embarrassment in essential tremor.
Article in Journal of clinical movement disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Essential tremor patients experience significant burden beyond tremor: A systematic literature review.Frontiers in neurology · 2022Pooled it
- Neuropsychiatric, stress-related symptoms and essential tremor clinical variability.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Wearable Ultrasound Sensing with Dual Arrays and Machine Learning for Real-Time Tremor Characterization and Antagonist Muscle Monitoring.IEEE transactions on instrumentation and measurement · 2026Article
- Stigma and Social Avoidance in Adults with Essential Tremor.Movement disorders clinical practice · 2023Article
- Modifiable risk factors of major depressive disorder: A Mendelian randomization study.PloS one · 2023Article
- Altered local and matrix functional connectivity in depressed essential tremor patients.BMC neurology · 2021Article
- Identifying Depressed Essential Tremor Using Resting-State Voxel-Wise Global Brain Connectivity: A Multivariate Pattern Analysis.Frontiers in human neuroscience · 2021Article
- Enfeeblement in Elders with Essential Tremor: Characterizing the Phenomenon and Its Role in Caregiver Burden.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Article
- Prevalence and Risk Factors of Depression and Anxiety in Essential Tremor Patients: A Cross-Sectional Study in Southwest China.Frontiers in neurology · 2019Article
- What Predicts Mortality in Essential Tremor? A Prospective, Longitudinal Study of Elders.Frontiers in neurology · 2018Article
- Brainstem Raphe Alterations in TCS: A Biomarker for Depression and Apathy in Parkinson's Disease Patients.Frontiers in neurology · 2018Article
- Perceived embarrassment and caregiver burden in essential tremor caregivers.Journal of the neurological sciences · 2017Article
- Is there a Premotor Phase of Essential Tremor?Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
- Computational modeling to improve treatments for essential tremor.Drug discovery today. Disease models · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEmbarrassment can be a considerable problem for patients with essential tremor (ET) and is a major motivator for treatment. Depression is also a common feature of ET; as many as 35 % of patients report moderate to severe depressive symptoms. Our goal was to assess the associations between these motor and psychosocial factors (tremor, depression, embarrassment) in ET, with a particular interest in more fully assessing the possible association between depression and embarrassment.
methodsNinety one ET cases (age 70.4 ± 12.8 years) enrolled in a prospective, clinical-epidemiological study. Depressive symptoms were assessed with the Center for Epidemiological Studies Depression Scale (CESD-10, 0-30 [maximum]), embarrassment, with the Essential Tremor Embarrassment Assessment (ETEA, 0-70 [maximum]), and action tremor, with a detailed in-person neurological examination.
resultsHigher CESD-10 score was significantly associated with higher ETEA score (p = 0.005), but not with increasing tremor severity (p = 0.94). In stratified analyses, cases with no or minimal depressive symptoms had the lowest ETEA scores, cases with moderate depressive symptoms had intermediate ETEA scores, and cases with severe depressive symptoms had the highest ETEA scores (p = 0.01). Furthermore, at each level of tremor severity, cases with more depressive symptoms had more embarrassment.
conclusionsDepressive symptoms seem to be more than a secondary response to the tremor in ET; they seem to amplify the level of embarrassment and, in addition to their own importance, seem to be a driver of other important clinical outcomes. Earlier treatment of depressive symptoms in ET patients could lessen the burden of secondary embarrassment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.