ArticleOxidative medicine and cellular longevity2016
Parishin from Gastrodia elata Extends the Lifespan of Yeast via Regulation of Sir2/Uth1/TOR Signaling Pathway.
Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Parishin Alleviates Pulmonary Fibrosis by Reducing CD38 Levels in Naturally Aging Mice.Rejuvenation research · 2025Article
- Parishin A ameliorates cognitive decline by promoting PS1 autophagy in Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Genome-wide identification of glycoside hydrolase family 1 members reveals GeBGL1 and GeBGL9 for degrading gastrodin in Gastrodia elata.Plant cell reports · 2024Article
- Evaluating How Different Drying Techniques Change the Structure and Physicochemical and Flavor Properties ofFoods (Basel, Switzerland) · 2024Article
- Parishin alleviates vascular ageing in mice by upregulation of Klotho.Journal of cellular and molecular medicine · 2023Article
- Exploring the anti-aging potential of natural products and plant extracts in budding yeastF1000Research · 2023Review
- pH as a Key Factor for the Quality Assurance of the Preparation ofMolecules (Basel, Switzerland) · 2022Article
- Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner.Frontiers in microbiology · 2022Article
- Oral administration of hepcidin and chitosan benefits growth, immunity, and gut microbiota in grass carp (Frontiers in immunology · 2022Article
- Ameliorative Effect of Parishin C Against Cerebral Ischemia-Induced Brain Tissue Injury by Reducing Oxidative Stress and Inflammatory Responses in Rat Model.Neuropsychiatric disease and treatment · 2021Article
- Ehretiquinone fromOxidative medicine and cellular longevity · 2021Article
- Gentiopicroside, a Secoiridoid Glycoside fromOxidative medicine and cellular longevity · 2020Article
- Amarogentin fromOxidative medicine and cellular longevity · 2020Article
- Transformation Mechanisms of Chemical Ingredients in Steaming Process ofMolecules (Basel, Switzerland) · 2019Article
- Optimal Extraction Study of Gastrodin-Type Components fromMolecules (Basel, Switzerland) · 2019Article
- Antiaging, Stress Resistance, and Neuroprotective Efficacies ofOxidative medicine and cellular longevity · 2019Article
- Article
- Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress.Oxidative medicine and cellular longevity · 2019Article
- Structure Characterization and Action Mechanism of an Antiaging New Compound fromOxidative medicine and cellular longevity · 2019Article
- Antiaging of Cucurbitane Glycosides from Fruits ofOxidative medicine and cellular longevity · 2018Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parishin is a phenolic glucoside isolated from Gastrodia elata, which is an important traditional Chinese medicine; this glucoside significantly extended the replicative lifespan of K6001 yeast at 3, 10, and 30 μM. To clarify its mechanism of action, assessment of oxidative stress resistance, superoxide dismutase (SOD) activity, malondialdehyde (MDA), and reactive oxygen species (ROS) assays, replicative lifespans of sod1, sod2, uth1, and skn7 yeast mutants, and real-time quantitative PCR (RT-PCR) analysis were conducted. The significant increase of cell survival rate in oxidative stress condition was observed in parishin-treated groups. Silent information regulator 2 (Sir2) gene expression and SOD activity were significantly increased after treating parishin in normal condition. Meanwhile, the levels of ROS and MDA in yeast were significantly decreased. The replicative lifespans of sod1, sod2, uth1, and skn7 mutants of K6001 yeast were not affected by parishin. We also found that parishin could decrease the gene expression of TORC1, ribosomal protein S26A (RPS26A), and ribosomal protein L9A (RPL9A) in the target of rapamycin (TOR) signaling pathway. Gene expression levels of RPS26A and RPL9A in uth1, as well as in uth1, sir2 double mutants, were significantly lower than those of the control group. Besides, TORC1 gene expression in uth1 mutant of K6001 yeast was inhibited significantly. These results suggested that parishin exhibited antiaging effects via regulation of Sir2/Uth1/TOR signaling pathway.
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