SynthesisThe western journal of emergency medicine2016
Impact of Prehospital Care on Outcomes in Sepsis: A Systematic Review.
Synthesis in The western journal of emergency medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03919851 (Physician Administered Antibiotics in a Prehospital Mobile Emergency Care Unit), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physician Administered Antibiotics in a Prehospital Mobile Emergency Care Unit
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Prehospital Administration of Antibiotics for Patients with Suspected Severe Infection: A Systematic Review and Meta Analysis.Antibiotics (Basel, Switzerland) · 2026Review
- Direct admission to the intensive care unit for patients with prehospital septic shock is associated with a lower 30-day mortality rate.Scientific reports · 2026Article
- Interpretation Accuracy and Theoretical Decision Impact of Prehospital Ultrasound for Paramedics - Analysis of a Rural Pilot Program.Prehospital emergency care · 2026Observational
- Unplanned re-attendance to emergency department of patients with systemic inflammatory response syndrome: a situational analysis.BMC health services research · 2025Article
- Sepsis management in pre-hospital care - the earlier, the better?BMC emergency medicine · 2024Article
- Impact of Prehospital Ultrasound Training on Simulated Paramedic Clinical Decision-Making.The western journal of emergency medicine · 2024Article
- Prehospital early warning scores for adults with suspected sepsis: the PHEWS observational cohort and decision-analytic modelling study.Health technology assessment (Winchester, England) · 2024Observational
- Head-to-head comparison of pre-hospital qSOFA and lactate-qSOFA for predicting sepsis in patients with and without suspected infection. A multicenter prospective cohort study.Archives of medical science : AMS · 2024Article
- Does Being Transported by Emergency Medical Services Improve Compliance with the Surviving Sepsis Bundle and Mortality Rate? A Retrospective Cohort Study.Journal of epidemiology and global health · 2020Article
- Telephonic description of sepsis among callers to an emergency dispatch centre in South Africa.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2020Article
- Screening strategies to identify sepsis in the prehospital setting: a validation study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- Care of the patient with invasive meningococcal disease by prehospital emergency medical service clinicians: a scoping review.BMJ open · 2020Article
- [Consensus document for sepsis code implementation and development in the Community of Madrid].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019Article
- [Sepsis detection in emergency medicine : Results of an interprofessional survey on sepsis detection in prehospital emergency medicine and emergency departments].Der Anaesthesist · 2018Article
- Understanding the Knowledge and Attitude of Prehospital Sepsis Care among Emergency Medical Service Personnel.Journal of emergencies, trauma, and shockArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionSepsis is a common and potentially life-threatening response to an infection. International treatment guidelines for sepsis advocate that treatment be initiated at the earliest possible opportunity. It is not yet clear if very early intervention by ambulance clinicians prior to arrival at hospital leads to improved clinical outcomes among sepsis patients. METHODA: We systematically searched the electronic databases MEDLINE, EMBASE, CINAHL, the Cochrane Library and PubMed up to June 2015. In addition, subject experts were contacted. We adopted the GRADE (grading recommendations assessment, development and evaluation) methodology to conduct the review and follow PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations to report findings.
resultsNine studies met the eligibility criteria - one study was a randomized controlled trial while the remaining studies were observational in nature. There was considerable variation in the methodological approaches adopted and outcome measures reported across the studies. Because of these differences, the studies did not answer a unique research question and meta-analysis was not appropriate. A narrative approach to data synthesis was adopted.
conclusionThere is little robust evidence addressing the impact of prehospital interventions on outcomes in sepsis. That which is available is of low quality and indicates that prehospital interventions have limited impact on outcomes in sepsis beyond improving process outcomes and expediting the patient's passage through the emergency care pathway. Evidence indicating that prehospital antibiotic therapy and fluid resuscitation improve patient outcomes is currently lacking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.