Evidence map›Paper›PMID 27429642›Full record

ReviewWorld journal of emergency surgery : WJES2016

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Massimo Sartelli, Dieter G Weber, Etienne Ruppé, Matteo Bassetti, Brian J Wright, Luca Ansaloni, Fausto Catena, Federico Coccolini, Fikri M Abu-Zidan, Raul Coimbra and 163 more

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of emergency surgery : WJES, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 92 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 7 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 7 syntheses or guidelines pooled it, 197 citations in OpenAlex.

  1. Pooled it
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  5. Perforated and bleeding peptic ulcer: WSES guidelines.World journal of emergency surgery : WJES · 2020
    Guideline
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  16. Observational
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

173 authors at 20 institutions in 74 countries.

Massimo SartelliDepartment of Surgery, Macerata Hospital, Via Santa Lucia 2, 62100 Macerata, Italy.
Dieter G WeberDepartment of Trauma Surgery, Royal Perth Hospital, Perth, Australia.
Etienne RuppéGenomic Research Laboratory, Geneva University Hospitals, Geneva, Switzerland.
Matteo BassettiInfectious Diseases Division, Santa Maria Misericordia University Hospital, Udine, Italy.
Brian J WrightDepartment of Emergency Medicine and Surgery, Stony Brook University School of Medicine, Stony Brook, NY USA.
Luca AnsaloniGeneral Surgery Department, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Fausto CatenaDepartment of General, Maggiore Hospital, Parma, Italy.
Federico CoccoliniDepartment of Surgery, "Infermi" Hospital, Rimini, Italy.
Fikri M Abu-ZidanDepartment of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates.
Raul CoimbraDepartment of Surgery, UC San Diego Medical Center, San Diego, USA.
Ernest E MooreDepartment of Surgery, University of Colorado, Denver Health Medical Center, Denver, CO USA.
Frederick A MooreDepartment of Surgery, Division of Acute Care Surgery, and Center for Sepsis and Critical Illness Research, University of Florida College of Medicine, Gainesville, FL USA.
Ronald V MaierDepartment of Surgery, University of Washington, Seattle, WA USA.
Jan J De WaeleDepartment of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.
Andrew W KirkpatrickGeneral, Acute Care, and Trauma Surgery, Foothills Medical Centre, Calgary, AB Canada.
Ewen A GriffithsGeneral and Upper GI Surgery, Queen Elizabeth Hospital, Birmingham, UK.
Christian EckmannDepartment of General, Visceral, and Thoracic Surgery, Klinikum Peine, Academic Hospital of Medical University Hannover, Peine, Germany.
Adrian J BrinkDepartment of Clinical microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg, South Africa.
John E MazuskiDepartment of Surgery, School of Medicine, Washington University in Saint Louis, Missouri, USA.
Addison K MayDepartments of Surgery and Anesthesiology, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN USA.
Rob G SawyerDepartment of Surgery, University of Virginia Health System, Charlottesville, VA USA.
Dominik MertzDepartments of Medicine, Clinical Epidemiology and Biostatistics, and Pathology and Molecular Medicine, McMaster University, Hamilton, ON Canada.
Philippe MontraversDépartement d'Anesthésie-Réanimation, CHU Bichat Claude-Bernard-HUPNVS, Assistance Publique-Hôpitaux de Paris, University Denis Diderot, Paris, France.
Anand KumarSection of Critical Care Medicine and Section of Infectious Diseases, Department of Medicine, Medical Microbiology and Pharmacology/Therapeutics, University of Manitoba, Winnipeg, MB Canada.
Jason A RobertsAustralia Pharmacy Department, Royal Brisbane and Womens' Hospital; Burns, Trauma, and Critical Care Research Centre, Australia School of Pharmacy, The University of Queensland, Brisbane, QLD Australia.
Jean-Louis VincentDepartment of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium.
Richard R WatkinsDepartment of Internal Medicine, Division of Infectious Diseases, Akron General Medical Center, Northeast Ohio Medical University, Akron, OH USA.
Warren LowmanClinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Brad SpellbergDivision of Infectious Diseases, Los Angeles County-University of Southern California (USC) Medical Center, Keck School of Medicine at USC, Los Angeles, CA USA.
Iain J AbbottDepartment of Infectious Diseases, Alfred Hospital, Melbourne, VIC Australia.
Abdulrashid Kayode AdesunkanmiDepartment of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Sara Al-DahirDivision of Clinical and Administrative Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA USA.
Majdi N Al-HasanDepartment of Medicine, Division of Infectious Diseases, University of South Carolina School of Medicine, Columbia, SC USA.
Ferdinando AgrestaGeneral Surgery, ULSS19 del Veneto, Adria Hospital, RO, Italy.
Asma A AlthaniBiomedical Research Center, Qatar University, Doha, Qatar.
Shamshul AnsariDepartment of Microbiology, Chitwan Medical College, and Department of Environmental and Preventive Medicine, Oita University, Oita, Japan.
Rashid AnsumanaCentre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, University of Liverpool, and Mercy Hospital Research Laboratory, Njala University, Bo, Sierra Leone.
Goran AugustinDepartment of Surgery, University Hospital Center, Zagreb, Croatia.
Miklosh BalaTrauma and Acute Care Surgery Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Zsolt J BaloghDepartment of Traumatology, John Hunter Hospital and University of Newcastle, Newcastle, NSW Australia.
Oussama BaraketDepartment of Surgery, Bizerte Hospital, Bizerte, Tunisia.
Aneel BhanguAcademic Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK.
Marcelo A BeltránDepartment of General Surgery, Hospital San Juan de Dios de La Serena, La Serena, Chile.
Michael BernhardEmergency Department, University of Leipzig, Leipzig, Germany.
Walter L BifflDepartment of Surgery, University of Colorado, Denver, CO USA.
Marja A BoermeesterDepartment of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
Stephen M BrecherDepartment of Pathology and Laboratory Medicine, VA Boston HealthCare System, and Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA USA.
Jill R Cherry-BukowiecDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI USA.
Otmar R BuyneDepartment of Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Miguel A CainzosDepartment of Surgery, Hospital Clínico Universitario, Santiago de Compostela, Spain.
Kelly A CairnsPharmacy Department, Alfred Health, Melbourne, VIC Australia.
Adrian Camacho-OrtizHospital Epidemiology and Infectious Diseases, Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Mexico.
Sujith J ChandyDepartment of Pharmacology, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala India.
Asri Che JusohDepartment of General Surgery, Kuala Krai Hospital, Kuala Krai, Kelantan Malaysia.
Alain Chichom-MefireDepartment of Surgery and Obstetrics/Gynaecology, Regional Hospital, Limbe, Cameroon.
Caroline ColijnDepartment of Mathematics, Imperial College London, London, UK.
Francesco CorcioneDepartment of Laparoscopic and Robotic Surgery, Colli-Monaldi Hospital, Naples, Italy.
Yunfeng CuiDepartment of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin, China.
Daniel CurcioInfectología Institucional SRL, Hospital Municipal Chivilcoy, Buenos Aires, Argentina.
Samir DelibegovicDepartment of Surgery, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina.
Zaza DemetrashviliDepartment General Surgery, Kipshidze Central University Hospital, Tbilisi, Georgia.
Belinda De SimoneDepartment of Surgery, Quatre Villes Hospital, St Cloud, France.
Sameer DhingraSchool of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Eric Williams Medical Sciences Complex, Uriah Butler Highway, Champ Fleurs, Trinidad and Tobago.
José J DiazDivision of Acute Care Surgery, Program in Trauma, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD USA.
Isidoro Di CarloDepartment of Surgical Sciences, Cannizzaro Hospital, University of Catania, Catania, Italy.
Angel DillipIfakara Health Institute, Dar es Salaam, Tanzania.
Salomone Di SaverioDepartment of Surgery, Maggiore Hospital, Bologna, Italy.
Michael P DoyleCenter for Food Safety, Department of Food Science and Technology, University of Georgia, Griffin, GA USA.
Gereltuya DorjSchool of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Agron DogjaniDepartment of Surgery, University Hospital of Trauma, Tirana, Albania.
Hervé DupontDépartement d'Anesthésie-Réanimation, CHU Amiens-Picardie, and INSERM U1088, Université de Picardie Jules Verne, Amiens, France.
Soumitra R EachempatiDepartment of Surgery, Division of Burn, Critical Care, and Trauma Surgery (K.P.S., S.R.E.), Weill Cornell Medical College/New York-Presbyterian Hospital, New York, USA.
Mushira Abdulaziz EnaniDepartment of Medicine, Infectious Disease Division, King Fahad Medical City, Riyadh, Saudi Arabia.
Valery N EgievDepartment of Surgery, Pirogov Russian National Research Medical University, Moscow, Russian Federation.
Mutasim M ElmangorySudan National Public Health Laboratory, Federal Ministry of Health, Khartoum, Sudan.
Paula FerradaDepartment of Surgery, Virginia Commonwealth University, Richmond, VA USA.
Joseph R FitchettDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Gustavo P FragaDivision of Trauma Surgery, Department of Surgery, School of Medical Sciences, University of Campinas (Unicamp), Campinas, SP Brazil.
Nathalie GuessenndInstitut Pasteur, Abidjan, Ivory Coast.
Helen Giamarellou6th Department of Internal Medicine, Hygeia General Hospital, Athens, Greece.
Wagih GhnnamDepartment of General Surgery, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.
George Gkiokas2nd Department of Surgery, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Staphanie R GoldbergDepartment of Surgery, Virginia Commonwealth University, Richmond, VA USA.
Carlos Augusto GomesDepartment of Surgery, Hospital Universitário Terezinha de Jesus, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, Brazil.
Harumi GomiCenter for Global Health, Mito Kyodo General Hospital, University of Tsukuba, Mito, Ibaraki Japan.
Manuel Guzmán-BlancoHospital Privado Centro Médico de Caracas and Hospital Vargas de Caracas, Caracas, Venezuela.
Mainul HaqueUnit of Pharmacology, Faculty of Medicine and Defense Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia.
Sonja HansenInstitute of Hygiene, Charité-Universitätsmedizin Berlin, Hindenburgdamm 27, 12203 Berlin, Germany.
Andreas HeckerDepartment of General and Thoracic Surgery, University Hospital Giessen, Giessen, Germany.
Wolfgang R HeizmannOrgamed Consulting, Bad Griesbach, Germany.
Torsten HerzogDepartment of Surgery, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Adrien Montcho HodonouDepartment of Surgery, Faculté de médecine, Université de Parakou, BP 123 Parakou, Bénin.
Suk-Kyung HongDivision of Trauma and Surgical Critical Care, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Reinhold Kafka-RitschDepartment of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.
Lewis J KaplanDepartment of Surgery Philadelphia VA Medical Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Garima KapoorDepartment of Microbiology, Gandhi Medical College, Bhopal, India.
Aleksandar KaramarkovicClinic for Emergency Surgery, Medical Faculty University of Belgrade, Belgrade, Serbia.
Martin G KeesDepartment of Anesthesiology and Intensive Care, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
Jakub Kenig3rd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.
Ronald KigubaDepartment of Pharmacology and Therapeutics, College of Health Sciences, Makerere University, Kampala, Uganda.
Peter K KimDepartment of Surgery, Albert Einstein College of Medicine and Jacobi Medical Center, Bronx, NY USA.
Yoram KlugerDepartment of General Surgery, Division of Surgery, Rambam Health Care Campus, Haifa, Israel.
Vladimir KhokhaDepartment of Emergency Surgery, City Hospital, Mozyr, Belarus.
Kaoru KoikeDepartment of Primary Care and Emergency Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kenneth Y Y KokDepartment of Surgery, The Brunei Cancer Centre, Jerudong Park, Brunei.
Victory KongDepartment of Surgery, Edendale Hospital, Pietermaritzburg, South Africa.
Matthew C KnoxSchool of Medicine, Western Sydney University, Campbelltown, NSW Australia.
Kenji InabaDivision of Acute Care Surgery and Surgical Critical Care, Department of Surgery, Los Angeles County and University of Southern California Medical Center, University of Southern California, Los Angeles, CA USA.
Arda IsikDepartment of General Surgery, Erzincan University, Faculty of Medicine, Erzincan, Turkey.
Katia IskandarDepartment of Pharmacy, Lebanese International University, Beirut, Lebanon.
Rao R IvaturyDepartment of Surgery, Virginia Commonwealth University, Richmond, VA USA.
Maurizio LabbateSchool of Life Science and The ithree Institute, University of Technology, Sydney, NSW Australia.
Francesco M LabricciosaDepartment of Biomedical Sciences and Public Health, Unit of Hygiene, Preventive Medicine and Public Health, UNIVMP, Ancona, Italy.
Pierre-François LaterreDepartment of Critical Care Medicine, Cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCL), Brussels, Belgium.
Rifat LatifiDepartment of Surgery, Division of Trauma, University of Arizona, Tucson, AZ USA.
Jae Gil LeeDepartment of Surgery, Yonsei University College of Medicine, Seoul, South Korea.
Young Ran LeeTexas Tech University Health Sciences Center School of Pharmacy, Abilene, TX USA.
Marc LeoneDepartment of Anaesthesiology and Critical Care, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.
Ari LeppaniemiAbdominal Center, University Hospital Meilahti, Helsinki, Finland.
Yousheng LiDepartment of Surgery, Inling Hospital, Nanjing University School of Medicine, Nanjing, China.
Stephen Y LiangDivision of Infectious Diseases, Division of Emergency Medicine, Washington University School of Medicine, St. Louis, MO USA.
Tonny LohoDivision of Infectious Diseases, Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Marc MaegeleDepartment for Traumatology and Orthopedic Surgery, Cologne Merheim Medical Center (CMMC), University of Witten/Herdecke (UW/H), Cologne, Germany.
Sydney MalamaHealth Research Program, Institute of Economic and Social Research, University of Zambia, Lusaka, Zambia.
Hany E MareiBiomedical Research Center, Qatar University, Doha, Qatar.
Ignacio Martin-LoechesMultidisciplinary Intensive Care Research Organization (MICRO), Wellcome Trust-HRB Clinical Research, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James' University Hospital, Dublin, Ireland.
Sanjay MarwahDepartment of Surgery, Post-Graduate Institute of Medical Sciences, Rohtak, India.
Amos MasseleDepartment of Clinical Pharmacology, School of Medicine, University of Botswana, Gaborone, Botswana.
Michael McFarlaneDepartment of Surgery, Radiology, University Hospital of the West Indies, Kingston, Jamaica.
Renato Bessa MeloGeneral Surgery Department, Centro Hospitalar de São João, Porto, Portugal.
Ionut NegoiDepartment of Surgery, Emergency Hospital of Bucharest, Bucharest, Romania.
David P NicolauCenter of Anti-Infective Research and Development, Hartford, CT USA.
Carl Erik NordDepartment of Laboratory Medicine, Division of Clinical Microbiology, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Richard Ofori-AsensoResearch Unit, Health Policy Consult, Weija-Accra, Ghana.
AbdelKarim H OmariDepartment of Surgery, King Abdullah University Hospital, Irbid, Jordan.
Carlos A OrdonezDepartment of Surgery and Critical Care, Universidad del Valle, Fundación Valle del Lili, Cali, Colombia.
Mouaqit OuadiiDepartment of Surgery, Hassan II University Hospital, Medical School of Fez, Sidi Mohamed Benabdellah University, Fez, Morocco.
Gerson Alves Pereira JúniorDivision of Emergency and Trauma Surgery, Ribeirão Preto Medical School, Ribeirão Preto, Brazil.
Diego PiazzaDivision of Surgery, Vittorio Emanuele Hospital, Catania, Italy.
Guntars PupelisDepartment of General and Emergency Surgery, Riga East University Hospital 'Gailezers', Riga, Latvia.
Timothy Miles RawsonNational Institute for Health Research, Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, London, UK.
Miran RemsDepartment of General Surgery, Jesenice General Hospital, Jesenice, Slovenia.
Sandro RizoliTrauma and Acute Care Service, St Michael's Hospital, University of Toronto, Toronto, Canada.
Claudio RochaU.S. Naval Medical Research Unit N° 6, Callao, Peru.
Boris SakakushevGeneral Surgery Department, Medical University, University Hospital St George, Plovdiv, Bulgaria.
Miguel Sanchez-GarciaIntensive Care Department, Hospital Clínico San Carlos, Madrid, Spain.
Norio SatoDepartment of Primary Care and Emergency Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Helmut A Segovia LohseII Cátedra de Clínica Quirúrgica, Hospital de Clínicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay.
Gabriele SgangaDepartment of Surgery, Catholic University of Sacred Heart, Policlinico A Gemelli, Rome, Italy.
Boonying SiribumrungwongDepartment of Surgery, Faculty of Medicine, Thammasat University Hospital, Thammasat University, Pathum Thani, Thailand.
Vishal G ShelatDepartment of General Surgery, Tan Tock Seng Hospital, Tan Tock Seng, Singapore.
Kjetil SoreideDepartment of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Rodolfo SotoDepartment of Emergency Surgery and Critical Care, Centro Medico Imbanaco, Cali, Colombia.
Peep TalvingDepartment of Surgery, North Estonia Medical Center, Tallinn, Estonia.
Jonathan V TilsedSurgery Health Care Group, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.
Jean-Francois TimsitAPHP medical and infectious diseases ICU, Bichat Hospital, Paris, France.
Gabriel TruebaInstitute of Microbiology, Biological and Environmental Sciences College, University San Francisco de Quito, Quito, Ecuador.
Ngo Tat TrungDepartment of Molecular Biology, Tran Hung Dao Hospital, No 1, Tran Hung Dao Street, Hai Ba Trung Dist, Hanoi, Vietnam.
Jan Ulrych1st Department of Surgery - Department of Abdominal, Thoracic Surgery and Traumatology, General University Hospital, Prague, Czech Republic.
Harry van GoorDepartment of Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Andras VereczkeiDepartment of Surgery, Medical School University of Pécs, Pécs, Hungary.
Ravinder S VohraNottingham Oesophago-Gastric Unit, Nottingham University Hospitals, Nottingham, UK.
Imtiaz WaniDepartment of Surgery, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India.
Waldemar UhlDepartment of Surgery, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Yonghong XiaoState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affilliated Hospital, Zhejiang University, Zhejiang, China.
Kuo-Ching YuanTrauma and Emergency Surgery Department, Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
Sanoop K ZachariahDepartment of Surgery, MOSC Medical College Kolenchery, Cochin, India.
Jean-Ralph ZaharInfection Control Unit, Angers University, CHU d'Angers, Angers, France.
Tanya L ZakrisonDivision of Trauma and Surgical Critical Care, DeWitt Daughtry Family Department of Surgry, University of Miami, Miami, FL USA.
Antonio CorcioneAnesthesia and Intensive Care Unit, AORN dei Colli Vincenzo Monaldi Hospital, Naples, Italy.
Rita M MelottiAnesthesiology and Intensive Care Unit, Sant'Orsola University Hospital, Bologna, Italy.
Claudio ViscoliInfectious Diseases Unit, University of Genoa (DISSAL) and IRCCS San Martino-IST, Genoa, Italy.
Perluigi VialeInfectious Diseases Unit, Department of Medical and Surgical Sciences, Sant' Orsola Hospital, University of Bologna, Bologna, Italy.
Virginia Commonwealth University · USCharité - Universitätsmedizin Berlin · DEKyoto University · JPOspedale Monaldi · ITQatar University · QAQueen Elizabeth Hospital Birmingham · GBRadboud University Nijmegen · NLSt. Josef-Hospital · DEUniversity of Southern California · USWashington University in St. Louis · US9th City Clinical Hospital · BYAix-Marseille Université · FRAkron General Medical Center · USAlbert Einstein College of Medicine · USAlfred Health · AUAmsterdam UMC Location University of Amsterdam · NLAssistance Publique – Hôpitaux de Paris · FRAzienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele · ITBoston University · USBrunei Polytechnic · BN

Funding

Xavier's RCMI Cancer Research ProgramG12MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE, WANG, GUANGDI · 2012 to 2018
$15.7M
Transferrin Combination Therapy to Address Antimicrobial ResistanceR01AI117211 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2016 to 2019
$2.7M
NIAID NIH HHS R01 AI117211NIMHD NIH HHS G12 MD007595
6 · The paper itself

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Indexed as

International CooperationIntraabdominal InfectionsAnti-Infective AgentsDrug Resistance, MicrobialHumansMicrobial Sensitivity TestsPrognosisAnti-Infective Agents

Identifiers

PMID27429642
PMCPMC4946132
OpenAlexW2473138844

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.