Evidence map›Paper›PMID 27429592›Full record

ArticleInternational journal of medical sciences2016

Association between Interleukin-18 Polymorphisms and Hepatocellular Carcinoma Occurrence and Clinical Progression.

Hon-Kit Lau, Ming-Ju Hsieh, Shun-Fa Yang, Hsiang-Ling Wang, Wu-Hsien Kuo, Hsiang-Lin Lee, Chao-Bin Yeh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  12. Variations in theInternational journal of medical sciences · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hon-Kit Lau1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 2. Department of Anaesthesiology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Ming-Ju Hsieh1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 3. Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan; 4. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Shun-Fa Yang1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 5. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Hsiang-Ling Wang1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 6. Department of Beauty Science, National Taichung University of Science and Technology, Taichung, Taiwan.
Wu-Hsien Kuo7. Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
Hsiang-Lin Lee1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 8. Deptartment of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chao-Bin Yeh9. Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 10. Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chung Shan Medical University · TWChung Shan Medical University Hospital · TWKaohsiung Armed Forces General Hospital · TWNational Taichung University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the association between interleukin-18 (IL-18) polymorphisms and the susceptibility and clinicopathological state of hepatocellular carcinoma (HCC). In total, 901 participants, including 559 healthy controls and 342 patients with HCC, were recruited. The allelic discrimination of -607A/C (rs1946518) and -137G/C (rs187238) polymorphisms of IL-18 was assessed through real-time polymerase chain reaction by performing the TaqMan assay. The IL-18 -137G/C polymorphism but not the -607A/C polymorphism showed a significant association with the risk of HCC. Participants carrying the IL-18 -137 polymorphism with heterozygous G/C and homozygous CC genotypes showed a 1.987-fold increase (95% CI = 1.301-3.032; p = 0.001) in the risk of HCC compared with those homozygous for wild-type G/G. The 342 patients with HCC carrying the IL-18 -137G/C polymorphism were positive for hepatitis B virus (HBV) infection with an adjusted odds ratio of 1.668. Moreover, the 142 HBV positive patients with HCC and the IL-18 -137 polymorphism were positive for at least one C genotype and showed significant vascular invasion (p = 0.018). Furthermore, the level of α-fetoprotein was high in the patients carrying the IL-18 -137 polymorphism with GC+CC alleles (p = 0.011). In conclusion, the IL-18 -137G/C polymorphism with a GC+CC genotype could be a factor that increases the risk of HCC. Furthermore, the correlation between the IL-18 -137G/C polymorphism and HCC-related HBV infection is a risk factor for vascular invasion and has a synergistic effect that can further enhance HCC prognosis.

Indexed as

Genetic Association StudiesAdultAllelesalpha-FetoproteinsCarcinoma, HepatocellularFemaleGenetic Predisposition to DiseaseGenotypeHepatitis B virusHumansInterleukin-18Liver NeoplasmsMaleMiddle AgedPolymorphism, Single NucleotideRisk Factorsalpha-FetoproteinsIL18 protein, humanInterleukin-18hepatitis B virushepatocellular carcinomainterleukin-18

Identifiers

PMID27429592
PMCPMC4946126
OpenAlexW2467765436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.