ArticleInternational journal of medical sciences2016
Effects of LG268 on Cell Proliferation and Apoptosis of NB4 Cells.
Article in International journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- MiR-9 functions as a tumor suppressor in acute myeloid leukemia by targeting CX chemokine receptor 4.American journal of translational research · 2019Article
- Preclinical Assessment of the Proliferation Capacity of Gingival and Periodontal Ligament Stem Cells from Diabetic Patients.Open access Macedonian journal of medical sciences · 2018Article
- Radiosensitization by CpG ODN7909 in an epidermoid laryngeal carcinoma Hep-2 cell line.The Journal of international medical research · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the effect of LG100268 (LG268) on cell proliferation and apoptosis in NB4 cells.
methodsNB4 cells were treated with LG268 for 24 h or 48 h. The effect of LG268 on cell proliferation was assessed by the CCK-8 assay and colony-forming assay. Apoptosis and cell cycle were evaluated by flow cytometry. The protein expression levels of Survivin, PARP, c-Myc, cyclin D1, ERK, p-ERK, p38 MAPK, and p- p38 MAPK were detected by western blot.
resultsWe found that LG268 inhibited the proliferation of NB4 cells in a dose-dependent manner. Flow cytometry analysis showed that LG268 accelerated apoptosis in NB4 cells in a time- dependent manner and that LG268 treatment led to cell cycle arrest at G0/G1 phase. Moreover, LG268 significantly decreased the protein levels of Survivin, c-Myc, and cyclinD1. Cleaved PARP was observed in the LG268 treatment group but not in the control group. In addition, LG268 increased the phosphorylation level of p38 MAPK and decreased the phosphorylation level of ERK.
conclusionsLG268 inhibited cell proliferation and promoted cell apoptosis in NB4 cells.
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