ArticlePediatric research2016
Alveolar formation is dysregulated by restricted nutrition but not excess sedation in preterm lambs managed by noninvasive support.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Early nutritional management and risk of neonatal bronchopulmonary dysplasia: a systematic review and mata analysis.Italian journal of pediatrics · 2025Pooled it
- [Association of early nutrition deficiency with the risk of bronchopulmonary dysplasia: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Pooled it
- Postnatal growth restriction impairs rat lung structure and function.Anatomical record (Hoboken, N.J. : 2007) · 2025Article
- Predictive value of serum MED1 and PGC-1α for bronchopulmonary dysplasia in preterm infants.BMC pulmonary medicine · 2024Observational
- Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Dose-dependent impact of human milk feeding on tidal breathing flow-volume loop parameters across the first 2 years of life in extremely low-birth-weight infants: a cohort study.European journal of pediatrics · 2023Article
- Hippocampal epigenetic and insulin-like growth factor alterations in noninvasive versus invasive mechanical ventilation in preterm lambs.Pediatric research · 2021Article
- Early extubation to noninvasive respiratory support of former preterm lambs improves long-term respiratory outcomes.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development.American journal of respiratory cell and molecular biology · 2021Article
- Non-invasive Respiratory Support of the Premature Neonate: From Physics to Bench to Practice.Frontiers in pediatrics · 2020Review
- Non-invasive measurements of respiratory system mechanical properties by the forced oscillation technique in spontaneously breathing, mixed-breed, normal term lambs from birth to five months of age.Physiological measurement · 2019Article
- Gestational Age Influences the Early Microarchitectural Changes in Response to Mechanical Ventilation in the Preterm Lamb Lung.Frontiers in pediatrics · 2019Article
- Former-preterm lambs have persistent alveolar simplification at 2 and 5 months corrected postnatal age.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Vitamin A Protects the Preterm Lamb Diaphragm Against Adverse Effects of Mechanical Ventilation.Frontiers in physiology · 2018Article
- Prevention of bronchopulmonary dysplasia: current strategies.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Preterm birth and ventilation decrease surface density of glomerular capillaries in lambs, regardless of postnatal respiratory support mode.Pediatric research · 2017Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPreterm birth and respiratory support with invasive mechanical ventilation frequently leads to bronchopulmonary dysplasia (BPD). A hallmark feature of BPD is alveolar simplification. For our preterm lamb model of BPD, invasive mechanical ventilation is associated with postnatal feeding intolerance (reduced nutrition) and sedation. In contrast, preterm lambs managed by noninvasive support (NIS) have normal alveolar formation, appropriate postnatal nutrition, and require little sedation. We used the latter, positive-outcome group to discriminate the contribution of reduced nutrition vs. sedation on alveolar simplification. We hypothesized that, restricted nutrition, but not sedation with pentobarbital, contributes to impaired indices of alveolar formation in preterm lambs managed by NIS.
methodsPreterm lambs managed by NIS for 21d were randomized into three groups: NIS control, NIS plus restricted nutrition, and NIS plus excess sedation with pentobarbital. We quantified morphological and biochemical indices of alveolar formation, as well as mesenchymal cell apoptosis and proliferation.
resultsRestricted nutrition impaired morphological and biochemical indices of alveolar formation, and reduced mesenchymal cell apoptosis and proliferation. Excess sedation with pentobarbital did not alter these indices, although mesenchymal cell apoptosis was less.
conclusionOur results demonstrate that restricted nutrition, but not excess sedation, contributes to impaired alveolar formation during the evolution of BPD in chronically ventilated preterm lambs.
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