Evidence map›Paper›PMID 27429191›Full record

ReviewJournal of acquired immune deficiency syndromes (1999)2016

Design Issues in Transgender Studies.

James P Hughes, Lynda Emel, Brett Hanscom, Sahar Zangeneh

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Providing Care for Transgender Persons With Kidney Disease: A Narrative Review.Canadian journal of kidney health and disease · 2021
    Review
  8. The Importance of Human Immunodeficiency Virus Research for Transgender and Gender-Nonbinary Individuals.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Review
  9. How Many Transgender Men Are There in San Francisco?Journal of urban health : bulletin of the New York Academy of Medicine · 2018
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

James P Hughes*Department of Biostatistics, University of Washington, Seattle, WA; and †Fred Hutchinson Cancer Research Center, Seattle, WA.
Lynda Emel
Brett Hanscom
Sahar Zangeneh
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
STATISTICAL ISSUES IN AIDS RESEARCHR37AI029168 · NIAID · UNIVERSITY OF WASHINGTON · PI JAMES P HUGHES · 1999 to 2026
$9.8M
STATISTICAL ISSUES IN AIDS RESEARCHR01AI029168 · NIAID · UNIVERSITY OF WASHINGTON · PI HUGHES, JAMES P · 1989 to 2018
$5.3M
NIAID NIH HHS R37 AI029168NIAID NIH HHS UM1 AI068617
6 · The paper itself

Abstract

Transgender individuals constitute an important focus for HIV prevention, but studies in this population present some unique methodologic and operational challenges. We consider issues related to sampling, sample size, number of sites, and trial cost. We discuss relevant design issues for evaluating interventions in both HIV-negative and HIV-infected transgender populations, as well as a method for assessing the impact of an intervention on population HIV incidence. We find that HIV-endpoint studies of transgender individuals will likely require fewer participants but more sites and have higher operational costs than HIV prevention trials in other populations. Because any intervention targeted to transgender individuals will likely include antiretroviral drugs, small scale studies looking at potential interactions between antiretroviral therapy and hormone therapy are recommended. Finally, assessing the impact of an intervention targeted to transgender individuals will require better information on the contribution of such individuals to the population HIV incidence.

Indexed as

Transgender PersonsClinical Trials as TopicCultural CompetencyFemaleHIV InfectionsHumansMalePatient Acceptance of Health CarePatient SelectionSample SizeSexual Behavior

Identifiers

PMID27429191
PMCPMC4955862
OpenAlexW2467257188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.