ArticlePsychosomatic medicine2017
Reciprocal Relationship Between Sleep Macrostructure and Evening and Morning Cellular Inflammation in Rheumatoid Arthritis.
Article in Psychosomatic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Proinflammatory Cytokines, Mood, and Sleep in Interepisode Bipolar Disorder and Insomnia: A Pilot Study With Implications for Psychosocial Interventions.Psychosomatic medicine · 2018Trial
- Sleep measurement and clinical impact in osteoarthritis and inflammatory arthritis: a scoping review.Rheumatology (Oxford, England) · 2026Article
- Central sensitization in rheumatoid arthritis and psoriatic arthritis is associated with symptom burden than inflammatory activity: a cross-sectional study.Rheumatology international · 2026Article
- Sleep improvement in patients with rheumatoid arthritis treated with upadacitinib in real-world practice: results from the SLEERA study.Arthritis research & therapy · 2026Observational
- The relationship between serum inflammatory cytokine levels and subjective sleep quality in chronic insomnia disorder.BMC psychiatry · 2026Article
- Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders.Biological psychiatry · 2025Review
- Sleep Measurement in Osteoarthritis and Inflammatory Arthritis: A Systematic Scoping Review Protocol.Musculoskeletal care · 2025Article
- Sleep disorders in rheumatoid arthritis, axial spondyloarthritis and psoriatic arthritis.Rheumatology international · 2025Review
- The Effects of Antioxidant Approved Drugs and Under Investigation Compounds with Potential of Improving Sleep Disorders and their Associated Comorbidities Associated with Oxidative Stress and Inflammation.Mini reviews in medicinal chemistry · 2025Review
- Relationship Between Sleep Disturbances and Chronic Pain: A Narrative Review.Clinics and practice · 2024Review
- Sleep Quality is Poor in Rheumatoid Arthritis Patients and Correlates with Anxiety, Depression, and Poor Quality of Life.Mediterranean journal of rheumatology · 2024Article
- Active Inflammatory Bowel Disease Is Associated with Short Sleep Duration via Objective Measures.Digestive diseases and sciences · 2024Observational
- Upsetting the Balance: How Modifiable Risk Factors Contribute to the Progression of Alzheimer's Disease.Biomolecules · 2024Review
- Analysis of the relationship between sleep-related disorder and systemic immune-inflammation index in the US population.BMC psychiatry · 2023Article
- Revisiting Asthma Obstructive Sleep Apnea Overlap: Current Knowledge and Future Needs.Journal of clinical medicine · 2023Review
- Article
- Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis.Nature reviews. Rheumatology · 2023Review
- Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature.Temperature (Austin, Tex.) · 2023Article
- Characterizing Patterns of Nurses' Daily Sleep Health: a Latent Profile Analysis.International journal of behavioral medicine · 2022Article
- Examining the Relationships Between Sleep Physiology and the Gut Microbiome in Preclinical and Translational Research: Protocol for a Scoping Review.JMIR research protocols · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study examined the reciprocal associations between sleep macrostructure and levels of cellular inflammation in rheumatoid arthritis (RA) patients and controls.
methodsRA patients (n = 24) and matched controls (n = 48) underwent all-night polysomnography, along with assessment of spontaneous- and Toll-like receptor-4-stimulated monocytic production of tumor necrosis factor α (TNF) and interleukin (IL)-6 at 11:00 PM and 8:00 AM.
resultsAs compared with controls, RA patients showed lower levels of sleep efficiency (mean [standard deviation], 88.1 [6.1] versus 83.8 [7.0]), a higher percentage stage 3 sleep (9.3 [6.4] versus 13.1 [6.9]), and higher levels of percentage of monocytes either spontaneously expressing TNF at 11:00 PM (log transformed, 1.07 [0.28] versus 1.22 [0.17]), and higher Toll-like receptor-4-stimulated production of IL6 at 8:00 AM (log transformed, 3.45 [0.80] versus 3.83 [0.39]). Higher levels of stimulated production of TNF at 11:00 PM were associated with higher sleep efficiency (0.74). In turn, sleep efficiency had a countervailing relationship on TNF production at 8:00 AM (-0.64). Higher levels of spontaneous and stimulated production of IL6 at 11:00 PM were associated with more stage 3 (0.39), stage 4 (0.43), and slow-wave sleep (0.49), with evidence that stage 4 had a countervailing relationship on IL6 production at 8:00 AM (-0.60).
conclusionsRA patients show evidence of sleep fragmentation, greater sleep depth, and higher levels of cellular inflammation. Sleep maintenance and sleep depth show countervailing relationships with evening and morning levels of monocytic production of TNF and IL-6, respectively, which support the hypothesis of a feedback loop between sleep maintenance, slow-wave sleep, and cellular inflammation that is cytokine specific.
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Registered trials
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