Evidence map›Paper›PMID 27428773›Full record

ArticleNature structural & molecular biology2016

Molecular architecture of the complete COG tethering complex.

Jun Yong Ha, Hui-Ting Chou, Daniel Ungar, Calvin K Yip, Thomas Walz, Frederick M Hughson

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. GARP Complex in Golgi Physiology.Sub-cellular biochemistry · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The machinery of vesicle fusion.Current opinion in cell biology · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Golgi inCOGnito: From vesicle tethering to human disease.Biochimica et biophysica acta. General subjects · 2020
    Review
  17. Review
  18. Article
  19. Integrative structure and function of the yeast exocyst complex.Protein science : a publication of the Protein Society · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun Yong HaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Hui-Ting ChouDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-8693-8571
Daniel UngarDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Calvin K YipDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Thomas WalzDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Frederick M HughsonDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

Funding

Single particle reconstructionP01GM062580 · NIGMS · HARVARD MEDICAL SCHOOL · PI HARRISON, STEPHEN COPLAN · 2001 to 2016
$23.7M
Structural Analysis of Membrane Tethering and Fusion ProteinsR01GM071574 · NIGMS · PRINCETON UNIVERSITY · PI HUGHSON, FREDERICK M · 2005 to 2024
$6.8M
NIGMS NIH HHS P01 GM062580NIGMS NIH HHS R01 GM071574
6 · The paper itself

Abstract

The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from that of the exocyst complex and appears to be well suited for vesicle capture and fusion.

Indexed as

Adaptor Proteins, Vesicular TransportGolgi ApparatusMicroscopy, ElectronMultiprotein ComplexesProtein Structure, QuaternarySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdaptor Proteins, Vesicular TransportMultiprotein ComplexesSaccharomyces cerevisiae Proteins

Identifiers

PMID27428773
PMCPMC4972656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.