ArticleNature genetics2016
Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank.
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 7 of them syntheses that pooled it.
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Who cites it
67 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- Meta-Analysis and Multivariate GWAS Analyses in 80,950 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure Traits.International journal of molecular sciences · 2023Pooled it
- Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.Nature genetics · 2022Pooled it
- Pooled it
- Gene-environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta-analyses of observational studies.International journal of cancer · 2019Pooled it
- Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort.Journal of medical genetics · 2018Pooled it
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.Nature genetics · 2018Pooled it
- Widespread and Biologically Driven Sex Disparities in Polygenic Risk Prediction Across Complex Traits.Research square · 2026Article
- Computationally efficient methods for estimating phenome-wide coheritability of multi-type phenotypes using biobank data.Communications biology · 2025Article
- Local genetic sex differences in quantitative traits.Nature communications · 2025Article
- BIGFAM - variance components analysis from relatives without genotype.Nature communications · 2025Article
- Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts.British journal of sports medicine · 2025Article
- A review of methods and software for polygenic risk score analysis.PeerJ. Computer science · 2025Article
- Heritability and shared environmental effects of brain diseases in 12,040 extended families.NPJ dementia · 2025Article
- Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study.Journal of the American Heart Association · 2024Article
- Cell-free DNA as a potential diagnostic biomarker in academic stress: A case-control study in young adults.Saudi journal of biological sciences · 2024Article
- Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles.Nature communications · 2023Article
- Canalization of the Polygenic Risk for Common Diseases and Traits in the UK Biobank Cohort.Molecular biology and evolution · 2022Article
- The alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Article
7 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
Genome-wide association studies have detected many loci underlying susceptibility to disease, but most of the genetic factors that contribute to disease susceptibility remain unknown. Here we provide evidence that part of the 'missing heritability' can be explained by an overestimation of heritability. We estimated the heritability of 12 complex human diseases using family history of disease in 1,555,906 individuals of white ancestry from the UK Biobank. Estimates using simple family-based statistical models were inflated on average by ∼47% when compared with those from structural equation modeling (SEM), which specifically accounted for shared familial environmental factors. In addition, heritabilities estimated using SNP data explained an average of 44.2% of the simple family-based estimates across diseases and an average of 57.3% of the SEM-estimated heritabilities, accounting for almost all of the SEM heritability for hypertension. Our results show that both genetics and familial environment make substantial contributions to familial clustering of disease.
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