Evidence map›Paper›PMID 27428650›Full record

ArticleNature neuroscience2016

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras Minhas, Alicia Viridiana Zamudio, Jia Meng, Feiran Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. MeCP2 is a naturally supercharged protein with cell membrane transduction capabilities.Protein science : a publication of the Protein Society · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Activation of βMolecular psychiatry · 2023
    Article
  18. Review
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Alexi NottThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jemmie ChengThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Fan GaoThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Yuan-Ta LinThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Elizabeta GjoneskaThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Tak KoThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Paras MinhasThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Alicia Viridiana ZamudioThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jia MengThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Feiran ZhangDepartment of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
Peng JinDepartment of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
Li-Huei TsaiThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Institute of Cognitive and Brain Sciences · USMassachusetts Institute of Technology · USEmory University · US

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Molecular Basis of rCGG-Mediated NeurodegenerationR01NS051630 · NINDS · EMORY UNIVERSITY · PI NELSON, DAVID LOREN · 2006 to 2023
$9.8M
The Epigenetics of Alzheimer's DiseaseR01NS078839 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2011 to 2015
$3.7M
Tet-mediated Epigenetic Modulation in AutismR01MH102690 · NIMH · EMORY UNIVERSITY · PI JIN, PENG, WARREN, STEPHEN T. · 2014 to 2017
$2.6M
5-Hydroxymethylcytosine in NeurodevelopmentR01NS079625 · NINDS · EMORY UNIVERSITY · PI JIN, PENG · 2012 to 2016
$1.7M
Dissecting the molecular basis of fragile X syndrome in DrosophilaR01MH076090 · NIMH · EMORY UNIVERSITY · PI JIN, PENG · 2006 to 2010
$1.6M
NIGMS NIH HHS T32 GM007287NIMH NIH HHS R01 MH076090NIMH NIH HHS R01 MH102690NINDS NIH HHS R01 NS051630NINDS NIH HHS R01 NS078839NINDS NIH HHS R01 NS079625
6 · The paper itself

Abstract

Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2

Indexed as

Social BehaviorAnimalsForkhead Transcription FactorsHistone Deacetylase 3Histone DeacetylasesHumansMethyl-CpG-Binding Protein 2Mice, TransgenicMutationNeural Stem CellsNeuronsPhenotypeRett SyndromeForkhead Transcription FactorsHistone Deacetylase 3Histone DeacetylasesMECP2 protein, humanMecp2 protein, mouseMethyl-CpG-Binding Protein 2

Identifiers

PMID27428650
PMCPMC5083138
OpenAlexW2491676496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.