ArticleNature plants2016
Genetic architecture and pleiotropy shape costs of Rps2-mediated resistance in Arabidopsis thaliana.
Article in Nature plants, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Harnessing Natural Diversity and Rational Design for Enhanced Plant Immunity.Plant, cell & environment · 2026Review
- No Cost of Resistance in Wheat Gene Stack Lines Containing 10 Stem Rust Resistance Transgenes.Plant biotechnology journal · 2026Article
- Natural variation in expression of a plant immune receptor mediates elicitor sensitivity.PloS one · 2026Article
- Natural variation in expression of a plant immune receptor mediates elicitor sensitivity.bioRxiv : the preprint server for biology · 2025Article
- Profile of Joy M. Bergelson.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Fitness benefits play a vital role in the retention of the Pi-ta susceptible alleles.Genetics · 2022Article
- Article
- A Truncated Singleton NLR Causes Hybrid Necrosis in Arabidopsis thaliana.Molecular biology and evolution · 2021Article
- Making sense of Integrated Pest Management (IPM) in the light of evolution.Evolutionary applications · 2020Article
- Population Genetics of the Highly PolymorphicGenes · 2019Article
- Article
- Alterations in Life-History Associated With Non-target-site Herbicide Resistance inFrontiers in plant science · 2019Article
- Molecular mechanisms that limit the costs of NLR-mediated resistance in plants.Molecular plant pathology · 2018Review
- Assortment of Flowering Time and Immunity Alleles in Natural Arabidopsis thaliana Populations Suggests Immunity and Vegetative Lifespan Strategies Coevolve.Genome biology and evolution · 2018Article
- Regulation and Evolution of NLR Genes: A Close Interconnection for Plant Immunity.International journal of molecular sciences · 2018Review
- Plant immunity in natural populations and agricultural fields: Low presence of pathogenesis-related proteins in Solanum leaves.PloS one · 2018Article
- Navigating complexity to breed disease-resistant crops.Nature reviews. Genetics · 2018Review
- Mechanisms to Mitigate the Trade-Off between Growth and Defense.The Plant cell · 2017Review
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3 authors at 1 institution in 1 country.
Funding
Abstract
The mounting evidence that R genes incur large fitness costs raises a question: how can there be a 5-10% fitness reduction for all 149 R genes in the Arabidopsis thaliana genome? The R genes tested to date segregate for insertion-deletion (indel) polymorphisms where susceptible alleles are complete deletions. Since costs of resistance are measured as the differential fitness of isolines carrying resistant and susceptible alleles, indels reveal costs that may be masked when susceptible alleles are expressed. Rps2 segregates for two expressed clades of alleles, one resistant and one susceptible. Plants with resistant Rps2 are not less fit than those with a susceptible Rps2 allele in the absence of disease. Instead, all alleles provide a fitness benefit relative to an artificial deletion because of the role of RPS2 as a negative regulator of defence. Our results highlight the interplay between genomic architecture and the magnitude of costs of resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.