ArticleNature chemical biology2016
Small-molecule antagonists of germination of the parasitic plant Striga hermonthica.
Article in Nature chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Strigolactones and sesquiterpene lactones induce Orobanche cumana germination via KAI2d receptors through distinct processes.The Plant journal : for cell and molecular biology · 2026Article
- Identification and structure-guided development of triazole urea-based selective antagonists of Arabidopsis karrikin signaling.Nature communications · 2025Article
- Small chemical molecules regulating the phytohormone signalling alter the plant's physiological processes to improve stress adaptation, growth and productivity.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Design, Synthesis and Biological Evaluation of Novel Phenyl-Substituted Naphthoic Acid Ethyl Ester Derivatives as Strigolactone Receptor Inhibitor.International journal of molecular sciences · 2024Article
- Unlocking the Multifaceted Mechanisms of Bud Outgrowth: Advances in Understanding Shoot Branching.Plants (Basel, Switzerland) · 2023Review
- Strigolactones: diversity, perception, and hydrolysis.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2023Article
- Article
- Emerging technologies for the chemical control of root parasitic weeds.Journal of pesticide science · 2022Article
- Probing strigolactone perception mechanisms with rationally designed small-molecule agonists stimulating germination of root parasitic weeds.Nature communications · 2022Article
- A novel strigolactone receptor antagonist provides insights into the structural inhibition, conditioning, and germination of the crop parasite Striga.The Journal of biological chemistry · 2022Article
- Rational design of Striga hermonthica-specific seed germination inhibitors.Plant physiology · 2022Article
- Expansion of the Strigolactone Profluorescent Probes Repertory: The Right Probe for the Right Application.Frontiers in plant science · 2022Article
- SeedQuant: a deep learning-based tool for assessing stimulant and inhibitor activity on root parasitic seeds.Plant physiology · 2021Article
- Molecular basis for high ligand sensitivity and selectivity of strigolactone receptors in Striga.Plant physiology · 2021Article
- Current progress in Striga management.Plant physiology · 2021Article
- The mechanism of host-induced germination in root parasitic plants.Plant physiology · 2021Review
- Structure-Function Analysis of SMAX1 Reveals Domains That Mediate Its Karrikin-Induced Proteolysis and Interaction with the Receptor KAI2.The Plant cell · 2020Article
- Molecular basis of strigolactone perception in root-parasitic plants: aiming to control its germination with strigolactone agonists/antagonists.Cellular and molecular life sciences : CMLS · 2020Review
- DiSCount: computer vision for automated quantification ofPlant methods · 2020Article
- Harnessing the microbiome to control plant parasitic weeds.Current opinion in microbiology · 2019Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Striga spp. (witchweed) is an obligate parasitic plant that attaches to host roots to deplete them of nutrients. In Sub-Saharan Africa, the most destructive Striga species, Striga hermonthica, parasitizes major food crops affecting two-thirds of the arable land and over 100 million people. One potential weakness in the Striga infection process is the way it senses the presence of a host crop. Striga only germinates in the presence of the plant hormone strigolactone, which exudes from a host root. Hence small molecules that perturb strigolactone signaling may be useful tools for disrupting the Striga lifecycle. Here we developed a chemical screen to suppress strigolactone signaling in the model plant Arabidopsis. One compound, soporidine, specifically inhibited a S. hermonthica strigolactone receptor and inhibited the parasite's germination. This indicates that strigolactone-based screens using Arabidopsis are useful in identifying lead compounds to combat Striga infestations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.