Evidence map›Paper›PMID 27428445›Full record

ArticleScandinavian journal of primary health care2016

Potentially severe drug-drug interactions among older people and associations in assisted living facilities in Finland: a cross-sectional study.

Mariko Teramura-Grönblad, Minna Raivio, Niina Savikko, Seija Muurinen, Helena Soini, Merja Suominen, Kaisu Pitkälä

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of primary health care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Drug-Related Problems and Polypharmacy in Nursing Home Residents: A Cross-Sectional Study.International journal of environmental research and public health · 2022
    Observational
  5. Observational
  6. Observational
  7. Article
  8. The use of proton pump inhibitors among older adults with intellectual disability: A cross sectional observational study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Article
  9. Are changes needed in the content of general practice?Scandinavian journal of primary health care · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mariko Teramura-Grönblada Home Care , City of Helsinki , Finland ;
Minna Raiviob University of Helsinki, Department of General Practice and Helsinki University Hospital , Unit of Primary Health Care , Finland ;
Niina Savikkob University of Helsinki, Department of General Practice and Helsinki University Hospital , Unit of Primary Health Care , Finland ;
Seija Muurinenb University of Helsinki, Department of General Practice and Helsinki University Hospital , Unit of Primary Health Care , Finland ;
Helena Soinib University of Helsinki, Department of General Practice and Helsinki University Hospital , Unit of Primary Health Care , Finland ;
Merja Suominenb University of Helsinki, Department of General Practice and Helsinki University Hospital , Unit of Primary Health Care , Finland ;
Kaisu Pitkäläb University of Helsinki, Department of General Practice and Helsinki University Hospital , Unit of Primary Health Care , Finland ;
Helsinki University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to assess potentially severe class D drug-drug interactions (DDDIs) in residents 65 years or older in assisted living facilities with the use of a Swedish and Finnish drug-drug interaction database (SFINX).

designA cross-sectional study of residents in assisted living facilities in Helsinki, Finland.

settingA total of 1327 residents were assessed in this study. Drugs were classified according to the Anatomical Therapeutic Chemical (ATC) classification system and DDDIs were coded according to the SFINX.

main outcome measuresPrevalence of DDDIs, associated factors and 3-year mortality among residents.

resultsOf the participants (mean age was 82.7 years, 78.3% were females), 5.9% (N = 78) are at risk for DDDIs, with a total of 86 interactions. Participants with DDDIs had been prescribed a higher number of drugs (10.8 (SD 3.8) vs. 7.9 (SD 3.7), p < 0.001). A larger proportion of residents with DDDIs suffered from rheumatoid arthritis or osteoarthritis than those not exposed to DDDIs (24.7% vs. 15.4%, p = 0.030). The most frequent DDDIs were related to the concomitant use of potassium with amiloride (N = 12) or spironolactone (N = 12). Carbamazepine (N = 13) and methotrexate (N = 9) treatments were also frequently linked to DDDIs. During the follow-up, no differences in mortality emerged between the participants exposed to DDDIs and the participants not exposed to DDDIs.

conclusionsOf the residents in assisted living, 5.9% were exposed to DDDIs associated with the use of a higher number of drugs. Physicians should be trained to find safer alternatives to drugs associated with DDDIs. KEY POINTS   Potentially severe, class D drug-drug interactions (DDDIs) have been defined in the SFINX database as clinically relevant drug interactions that should be avoided.  • Of the residents in assisted living, 5.9% were exposed to DDDIs that were associated with the use of a higher number of drugs.  • The most frequent DDDIs were related to the concomitant use of potassium with amiloride or spironolactone. Carbamazepine and methotrexate were also linked to DDDIs.  • No difference in mortality was observed between residents exposed to DDDIs and residents not exposed to DDDIs.

Indexed as

Drug InteractionsAgedAged, 80 and overAssisted Living FacilitiesChronic DiseaseComorbidityCross-Sectional StudiesDatabases, FactualFemaleFinlandHealth StatusHumansMaleMedication ErrorsMortalityPrevalenceAssisted livingdrug–drug interactionsFinlandgeneral practicemortality

Identifiers

PMID27428445
PMCPMC5036014
OpenAlexW2496817613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.