Observational studyMedicine2016
Risk factors of uveitis in ankylosing spondylitis: An observational study.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The association between ankylosing spondylitis and the risk of any, hip, or vertebral fracture: A meta-analysis.Medicine · 2017Pooled it
- Association of HLA-B27 with ankylosing spondylitis and clinical features of the HLA-B27-associated ankylosing spondylitis: a meta-analysis.Rheumatology international · 2017Pooled it
- Ocular Clues in Musculoskeletal Disorders: A Narrative Review for Orthopaedic Specialists.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Review
- Exploring the Genetic Association and Genetic Architecture of Iridocyclitis and Extraocular Autoimmune Diseases.Translational vision science & technology · 2026Article
- DEFB1 and NLRP3 gene variants are associated with acute anterior uveitis in ankylosing spondylitis: evidence of an innate immune interaction axis.International ophthalmology · 2025Article
- Association Between Adalimumab Dosing Interval and Uveitis Recurrence in Patients with Ankylosing Spondylitis.Biomedicines · 2025Article
- Predicting a diagnosis of ankylosing spondylitis using primary care health records-A machine learning approach.PloS one · 2023Article
- Extra-Articular Manifestations in Patients with Ankylosing Spondylitis: Baseline Characteristics from the RBSMR Study.Mediterranean journal of rheumatology · 2022Article
- Spectrum of Spondyloarthritis Among Chinese Populations.Current rheumatology reports · 2022Review
- The applicability of trabecular bone score for osteoporosis diagnosis in ankylosing spondylitis.Rheumatology international · 2022Article
- Investigation of Cas9 antibodies in the human eye.Nature communications · 2022Article
- A brief human history of ankylosing spondylitis: A scoping review of pathogenesis, diagnosis, and treatment.Surgical neurology international · 2022Article
- The Application of Artificial Intelligence in the Analysis of Biomarkers for Diagnosis and Management of Uveitis and Uveal Melanoma: A Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Uveitis in peripheral spondyloarthritis patients: an ancillary analysis of the ASAS-PerSpA study.Therapeutic advances in musculoskeletal disease · 2022Article
- A prospective study of novel disease activity indices for ankylosing spondylitis.Rheumatology international · 2020Article
- Radiographic Progression in Patients With Ankylosing Spondylitis According to Uveitis Based on the Observation Study of Korean Spondyloarthropathy Registry.Archives of rheumatology · 2020Article
- Uveitis in spondyloarthritis.Therapeutic advances in musculoskeletal disease · 2020Review
- New-Onset of Crohn's Disease Is Associated with Antistreptolysin O Positive Titers.Clinical and experimental gastroenterology · 2020Article
- Prefoldin 5 and Anti-prefoldin 5 Antibodies as Biomarkers for Uveitis in Ankylosing Spondylitis.Frontiers in immunology · 2019Article
- Advances in the treatment of uveitis in patients with spondyloarthritis - is it the time for biologic therapy?Romanian journal of ophthalmologyReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS). The prevalence and characteristics of uveitis in AS have been studied in previous literatures, whereas its associated risk factors have not been clarified. Therefore, this study analyzed the risk factors of uveitis in patients with AS.
methodsA total of 390 patients with AS who fulfilled the modified New York criteria were enrolled from January to December in 2015. The history of uveitis was accepted only if diagnosed by ophthalmologists. The medical records of the patients were retrospectively reviewed and associated information was collected, such as disease duration, HLA-B27, and the number of peripheral arthritis. Hip-joint lesion was identified by imaging examination. Meanwhile, biochemical examinations were performed to determine the patient's physical function.
resultsOf 390 patients with AS (80.5% male, mean age 33.3 years), 38 (9.7%) had experienced 1 or more episodes of uveitis. The incidence rate for hip-joint lesion was obviously higher for patients with uveitis than the nonuveitis group (44.7% vs 22.2%; P < 0.01). The number of peripheral arthritis was also larger for the uveitis group than nonuveitis group (2.18 ± 0.23 vs 0.55 ± 0.04; P < 0.001). Meanwhile, patients with uveitis had a significantly higher level of antistreptolysin O (ASO) and circulating immune complex (CIC) than those without (P < 0.05 and P < 0.0001, respectively). However, there were no significant differences in disease duration, HLA-B27, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) between the 2 groups. Binary logistic regression results showed that ASO (OR = 12.2, 95% CI:3.6-41.3, P < 0.01) and the number of peripheral arthritis (OR = 4.1, 95%CI:2.6-6.3, P < 0.01) are significantly associated with uveitis in AS. CONCLUSTION: This study provides some evidence that hip-joint lesion, the number of peripheral arthritis, ASO, and CIC may be associated with higher rates of uveitis in AS. The results of this comprehensive analysis suggest that the possible occurrence of uveitis in AS should not be neglected if the patients have those concomitant risk factors.
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