SynthesisMedicine2016
Body mass index and mortality in chronic obstructive pulmonary disease: A dose-response meta-analysis.
Synthesis in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 5 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- The impact of body mass index on mortality in COPD: an updated dose-response meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Pooled it
- PRISMA-compliant meta-analysis: association of metabolic syndrome and its components with the risk of chronic obstructive pulmonary disease.Bioscience reports · 2018Pooled it
- Exhaled nitric oxide in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease · 2018Pooled it
- The prevalence of metabolic syndrome in chronic obstructive pulmonary disease: A systematic review and meta-analysis.Chronic respiratory diseasePooled it
- Nutritional status and muscle mass loss in patients with COPD, association with lung function, symptoms, comorbidities and long-term survival: data from the National Database Study.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026Article
- Association Between Phase Angle, Muscle Mass Distribution, and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2026Article
- Relationship between the advanced lung cancer inflammation index (ALI) and all-cause and cause-specific mortality among patients with chronic obstructive pulmonary disease (COPD): a population-based study.BMC pulmonary medicine · 2026Article
- Long-term dynamic effect of body mass index on adverse cardiovascular outcomes with targeted maximum likelihood estimation method: result from the KNOW-CKD study.Scientific reports · 2026Article
- Development and validation of a BMI stratified mortality prediction model for patients with COPD complicated by HF using the MIMIC-IV database.Scientific reports · 2025Article
- The Impact of Obesity on Prostate Cancer and Progression to Castration Resistance-Real-World Data from a Romanian Center.Journal of clinical medicine · 2025Article
- The impact of body mass index on mortality according to age in hemodialysis patients: an analysis of the Korean Renal Data System.Kidney research and clinical practice · 2025Article
- NLRP3 is a BMI-independent mediator of stable COPD.BMC pulmonary medicine · 2025Article
- Spirometric pattern and cardiovascular risk: a prospective study of 0.3 million Chinese never-smokers.The Lancet regional health. Western Pacific · 2025Article
- Relationship between advanced lung cancer inflammation index and all-cause and cause-specific mortality among chronic inflammatory airway diseases patients: a population-based study.Frontiers in immunology · 2025Article
- Impact of Body Mass Index on Risk of Exacerbation in Patients With COPD: A Systematic Review and Meta-Analysis.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Associations of obesity with chronic inflammatory airway diseases and mortality in adults: a population-based investigation.BMC public health · 2024Article
- Comorbidities in COPD: Current and Future Treatment Challenges.Journal of clinical medicine · 2024Review
- Low Life Essential 8 Score as a Risk Factor for Long-Term Mortality in Chronic Obstructive Pulmonary Disease: A Study Based on the Analysis of NHANES Data from 2007 to 2012.International journal of chronic obstructive pulmonary disease · 2024Article
- Malnutrition and Obesity in Patients with COPD Exacerbation, Insights from the National Inpatient Sample.The open respiratory medicine journal · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to summarize the evidence on the dose-response relationship between body mass index (BMI) and mortality in patients with chronic obstructive pulmonary disease (COPD).We performed a systemic literature search in PubMed, Embase, and Web of Science for relevant studies that were published until June 2015. A random effects meta-analysis was used to estimate the pooled relative risks (RRs) of all-cause mortality in COPD patients with normal weight compared with those who were underweight, overweight, or obese. In addition, a dose-response meta-analysis was conducted to explore the dose-response relationship between BMI and all-cause mortality in COPD patients.A total of 17 observational studies involving 30,182 COPD patients among 285,960 participants were included. Compared with the reference category, the RRs of underweight, overweight, and obese individuals were 1.40 (95% confidence interval (CI), 1.20-1.63), 0.80 (95% CI, 0.67-0.96), and 0.77 (95% CI, 0.62-0.95), respectively. A significant nonlinear relationship between BMI and mortality of COPD patients was found by using a random effects model. COPD patients with BMI of <21.75 kg/m had a higher risk of death. Moreover, an increase in the BMI resulted in a decrease in the risk of death. The risk of death was lowest when BMI was 30 kg/m (RR = 0.69; 95% CI, 0.53-0.89). The BMI was not associated with all-cause mortality when BMI was >32 kg/m.Our findings indicate that overweight is associated with a lower risk of all-cause mortality among patients with COPD whereas underweight is associated with a higher risk of all-cause mortality in these patients. However, there is limited evidence to support the association between obesity and the risk of all-cause mortality in patients with COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.