ArticleCritical care medicine2016
Saline Is Not the First Choice for Crystalloid Resuscitation Fluids.
Article in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03340805 (Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Balanced crystalloid versus saline for resuscitation in pediatric septic shock: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Clinical efficacy of various resuscitation fluids in the management of sepsis in postoperative surgical and trauma patients: a systematic review and meta--analysis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Pooled it
- Clinical Effects of Balanced Crystalloids vs Saline in Adults With Diabetic Ketoacidosis: A Subgroup Analysis of Cluster Randomized Clinical Trials.JAMA network open · 2020Trial
- Balanced Crystalloids versus Saline in Noncritically Ill Adults.The New England journal of medicine · 2018Trial
- Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized Trial.American journal of respiratory and critical care medicine · 2017Trial
- Trial
- Trial
- Association of early crystalloid type with mortality and costs in acute pancreatitis: a nationwide cohort study.Journal of gastroenterology · 2026Article
- Lactated Ringer's solution versus normal saline outcomes in hospital settings: appraisal of a cluster-randomized trial.Internal and emergency medicine · 2026Article
- Preventive effect of sodium bicarbonate Ringer's solution on post-contrast acute kidney injury in patients undergoing percutaneous coronary intervention.Frontiers in pharmacology · 2025Article
- Normal saline versus Ringer's solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study.Journal of intensive care · 2024Article
- Intravenous fluid therapy in accordance with kidney injury risk: when to prescribe what volume of which solution.Clinical kidney journal · 2023Review
- The Efficacy and Safety of Sodium Bicarbonate Ringer's Solution in Critically Ill Patients: A Retrospective Cohort Study.Frontiers in pharmacology · 2022Article
- Normal Saline Solution or Lactated Ringer's Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial.Open access emergency medicine : OAEM · 2021Article
- Contemporary resuscitation of hemorrhagic shock: What will the future hold?American journal of surgery · 2020Review
- Fluid management in perioperative and critically ill patients.Acute and critical care · 2019Article
- Hyperchloraemia in sepsis.Annals of intensive care · 2018Review
- Normal saline for intravenous fluid therapy in critically ill patients.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Review
- Fluid resuscitation in critically ill patients: a systematic review and network meta-analysis.Therapeutics and clinical risk management · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.