ArticleBJOG : an international journal of obstetrics and gynaecology2016
Association of severe placental inflammation with death prior to discharge and cerebral palsy in preterm infants.
Article in BJOG : an international journal of obstetrics and gynaecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Chorioamnionitis in the Development of Cerebral Palsy: A Meta-analysis and Systematic Review.Pediatrics · 2017Pooled it
- Histological chorioamnionitis and developmental outcomes in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study.Frontiers in neurology · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of our study was to identify placental patterns associated with death before discharge or cerebral palsy in a large cohort of preterm infants with a high follow-up rate at 2 years of corrected age.
designPopulation-based monocentric study. SETTINGS: Monocentric study in the maternity unit of the University Hospital of Angers, France between 24 POPULATION: All singleton infants born alive with a placental examination were eligible.
methodsClinical data (obstetric and neonatal) were collected prospectively through the LIFT cohort. Placental data were collected retrospectively from medical records. The main outcome measure was death before discharge or cerebral palsy.
resultsWe did not find any significant association between severe inflammatory lesions on the placenta and death [odds ratio (OR) 1.49; 95% CI 0.55-4.01; P = 0.43] or cerebral palsy (OR 1.41; 95% CI 0.43-4.62; P = 0.57). This lack of significant association persisted even after adjustment (aOR 0.9; 95% CI 0.20-2.30; P = 0.54; aOR 0.98; 95% CI 0.27-3.58; P = 0.97).
conclusionOur results do not provide evidence for a significant association between severe inflammatory placental lesions and either death before discharge or cerebral palsy at 2 years of corrected age in preterm infants born at <34 weeks of gestational age. Further studies remain necessary to confirm this result. TWEETABLE ABSTRACT: We found no significant association between inflammatory placental lesions and death or cerebral palsy.
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