Evidence map›Paper›PMID 27427794›Full record

ArticleAntiviral therapy2016

Falls among middle-aged women in the Women's Interagency HIV Study.

Anjali Sharma, Donald R Hoover, Qiuhu Shi, Susan Holman, Michael W Plankey, Amber L Wheeler, Kathleen Weber, Michelle Floris-Moore, Hector H Bolivar, David E Vance and 4 more

Abstract read
In one paragraph

Article in Antiviral therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. A Fall Prevention Feasibility Trial for People With HIV and Alcohol Use.OTJR : occupation, participation and health · 2025
    Trial
  3. Effect of vitamin DAntiviral therapy · 2020
    Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Observational
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Obesity, Vascular Disease and Frailty in Aging Women with HIV.Advances in geriatric medicine and research · 2021
    Article
  17. Article
  18. Impaired Cognition Predicts Falls Among Women With and Without HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 14 institutions in 1 country.

Anjali SharmaDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Donald R HooverDepartment of Statistics and Biostatistics, Rutgers University, Piscataway, NJ, USA.
Qiuhu ShiDepartment of Epidemiology and Community Health, New York Medical College, Valhalla, NY, USA.
Susan HolmanDepartment of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
Michael W PlankeyDepartment of Medicine, Georgetown University Medical Center, Washington, DC, USA.
Amber L WheelerDepartment of Medicine, San Francisco VA Medical Center, San Francisco, CA, USA.
Kathleen WeberDepartment of Medicine, John H Stroger Jr Hospital of Cook County, Chicago, IL, USA.
Michelle Floris-MooreDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Hector H BolivarDepartment of Medicine, University of Miami Health System, Miami, FL, USA.
David E VanceSchool of Nursing, the University of Alabama at Birmingham, Birmingham, AL, USA.
Wendy J MackDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Elizabeth T GolubDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Marcia McDonnell HolstadOffice of Academic Advancement, Emory School of Nursing, Atlanta, GA, USA.
Michael T YinDepartment of Medicine, Columbia University Medical Center, New York, NY, USA.
Albert Einstein College of Medicine · USColumbia University Irving Medical Center · USEmory University · USGeorgetown University Medical Center · USJohn H. Stroger, Jr. Hospital of Cook County · USJohns Hopkins University · USNew York Medical College · USRutgers, The State University of New Jersey · USSan Francisco VA Medical Center · USSUNY Downstate Health Sciences University · USUniversity of Alabama at Birmingham · USUniversity of Miami Health System · USUniversity of North Carolina at Chapel Hill · USUniversity of Southern California · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Emory WIHS CRS - Longitudinal CohortU01AI103408 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WINGOOD, GINA MARIA · 2013 to 2018
$14.1M
UAB-MISS WIHS CohortU01AI103401 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEMPF, MIRJAM-COLETTE, KONKLE-PARKER, DEBORAH J · 2013 to 2018
$11.2M
University of North Carolina Womens Interagency HIV Study UNC WIHSU01AI103390 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADIMORA, ADAORA A · 2013 to 2018
$11.0M
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NIAID NIH HHS R01 AI095089NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NIAMS NIH HHS K23 AR061993NIAMS NIH HHS L30 AR063441NICHD NIH HHS U01 HD032632NIDA NIH HHS L30 DA029947
6 · The paper itself

Abstract

backgroundTo determine the frequency and risk factors for falls among middle-aged HIV+ and HIV- women in the Women's Interagency HIV Study (WIHS).

methodsWe quantified self-report of any and multiple (≥2) falls in the prior 6 months among 1,412 HIV+ and 650 HIV- women with mean age 48 years. Logistic regression was used to evaluate associations of demographics, behavioural factors, comorbid conditions and medications with odds of any fall (versus none) and multiple falls (versus ≤1 fall).

resultsAt least one fall was reported in 263 HIV+ (19%) versus 119 HIV- (18%) women, and ≥2 falls reported in 133 HIV+ (9%) versus 65 HIV- (10%) women. HIV infection was not associated with falls in multivariate analyses. Factors independently associated with any fall included age (adjusted odds ratio [aOR] 1.71, 95% CI 1.17, 2.49 age 50-59 versus <39 years; aOR 2.26, 95% CI 1.38, 3.71 age ≥60 versus <39), current marijuana use (aOR 2.19, 95% CI 1.53, 3.13) depressive symptoms (aOR 1.57, 95% CI 1.21, 2.05 for Center for Epidemiology Studies Depression score ≥16), subjective cognitive complaints (aOR 2.19, 95% CI 1.56, 3.08), neuropathy (aOR 1.59, 95% CI 1.19, 2.13), obesity (aOR 1.39, 95% CI 1.08, 1.80), number of central nervous system active agents (aOR 2.98, 95% CI 1.90, 4.68 for ≥3 agents versus 0) and WIHS site. Factors associated with ≥2 falls included age, marijuana use, number of central nervous system active agents, subjective cognitive complaints, depressive symptoms, neuropathy and study site.

conclusionsFalls were associated with factors affecting cognition, but not HIV status in this large cohort of women. Longitudinal studies are needed to determine the incidence and consequences of falls by HIV status as women age.

Indexed as

Accidental FallsAdultAgedAge FactorsCognitionCohort StudiesFemaleHIV InfectionsHumansLogistic ModelsMiddle AgedRisk Factors

Identifiers

PMID27427794
PMCPMC5243157
OpenAlexW2503900576

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.