ArticlePloS one2016
Genome-Wide Association Studies for Comb Traits in Chickens.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Bayesian fine-mapping pinpoints candidate genes and pleiotropic loci of production traits from a chicken backcrossing scheme.BMC genomics · 2026Article
- Unlocking growth potential in Wenchang chickens: A 21 K genotyping array for trait-associated structural variations.Poultry science · 2025Article
- Analysis of comb morphology in Sichuan Mountaineous Black-bone chickens and its correlation with growth performance.Poultry science · 2025Article
- The Omics Revolution in Understanding Chicken Reproduction: A Comprehensive Review.Current issues in molecular biology · 2024Review
- Analysis of the differentially expressed genes in the combs and testes of Qingyuan partridge roosters at different developmental stages.BMC genomics · 2024Article
- Identification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study.BMC genomics · 2023Article
- Genomic and gene expression associations to morphology of a sexual ornament in the chicken.G3 (Bethesda, Md.) · 2022Article
- Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study.BMC genomics · 2021Article
- Exploring the genetic architecture of feed efficiency traits in chickens.Scientific reports · 2021Article
- Genome-Wide Association Study Using Whole-Genome Sequencing Identifies a Genomic Region on Chromosome 6 Associated With Comb Traits in Nandan-Yao Chicken.Frontiers in genetics · 2021Article
- Genetic architecture related to contour feathers density in an F3 Biotech · 2019Article
- Bidirectional Selection for Body Weight on Standing Genetic Variation in a Chicken Model.G3 (Bethesda, Md.) · 2019Article
- Genome-wide association studies targeting the yield of extraembryonic fluid and production traits in Russian White chickens.BMC genomics · 2019Article
- Genetic architecture and candidate genes detected for chicken internal organ weight with a 600 K single nucleotide polymorphism array.Asian-Australasian journal of animal sciences · 2019Article
- Identification of potential genomic regions and candidate genes for egg albumen quality by a genome-wide association study.Archives animal breeding · 2019Article
- Identification of molecular pathways and candidate genes associated with cocks' comb size trait by genome-wide transcriptome analysis.Scientific reports · 2018Article
- Detection of QTL for greasy fleece weight in sheep using a 50 K single nucleotide polymorphism chip.Tropical animal health and production · 2017Article
- Genetic Architecture and Candidate Genes Identified for Follicle Number in Chicken.Scientific reports · 2017Article
- Annotating long intergenic non-coding RNAs under artificial selection during chicken domestication.BMC evolutionary biology · 2017Article
- A genome-wide study to identify genes responsible for oviduct development in chickens.PloS one · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The comb, as a secondary sexual character, is an important trait in chicken. Indicators of comb length (CL), comb height (CH), and comb weight (CW) are often selected in production. DNA-based marker-assisted selection could help chicken breeders to accelerate genetic improvement for comb or related economic characters by early selection. Although a number of quantitative trait loci (QTL) and candidate genes have been identified with advances in molecular genetics, candidate genes underlying comb traits are limited. The aim of the study was to use genome-wide association (GWA) studies by 600 K Affymetrix chicken SNP arrays to detect genes that are related to comb, using an F2 resource population. For all comb characters, comb exhibited high SNP-based heritability estimates (0.61-0.69). Chromosome 1 explained 20.80% genetic variance, while chromosome 4 explained 6.89%. Independent univariate genome-wide screens for each character identified 127, 197, and 268 novel significant SNPs with CL, CH, and CW, respectively. Three candidate genes, VPS36, AR, and WNT11B, were determined to have a plausible function in all comb characters. These genes are important to the initiation of follicle development, gonadal growth, and dermal development, respectively. The current study provides the first GWA analysis for comb traits. Identification of the genetic basis as well as promising candidate genes will help us understand the underlying genetic architecture of comb development and has practical significance in breeding programs for the selection of comb as an index for sexual maturity or reproduction.
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