Evidence map›Paper›PMID 27427553›Full record

Trial reportAsian journal of andrology

Exercise improves the effects of testosterone replacement therapy and the durability of response after cessation of treatment: a pilot randomized controlled trial.

Dae-Yeon Cho, Jeong Kyun Yeo, Seung Ik Cho, Jae Eun Jung, Sang Jin Yang, Doo Hwan Kong, Jeong Ku Ha, Jin Goo Kim, Min Gu Park

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Testosterone replacement in men with sexual dysfunction.The Cochrane database of systematic reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dae-Yeon ChoInje University, Sanggye Paik Hospital, Department of Urology, Seoul, Korea.
Jeong Kyun YeoInje University, Seoul Paik Hospital, Department of Urology, Seoul, Korea.
Seung Ik ChoKonKuk University Medical Center, Department of Orthopedics, Seoul, Korea.
Jae Eun JungInje University, Seoul Paik Hospital, Department of Orthopedics, Sports Medical Center, Seoul, Korea.
Sang Jin YangKonKuk University Medical Center, Department of Orthopedics, Seoul, Korea.
Doo Hwan KongInje University, Seoul Paik Hospital, Department of Orthopedics, Sports Medical Center, Seoul, Korea.
Jeong Ku HaInje University, Seoul Paik Hospital, Department of Orthopedics, Sports Medical Center, Seoul, Korea.
Jin Goo KimKonKuk University Medical Center, Department of Orthopedics, Seoul, Korea.
Min Gu ParkInje University, Seoul Paik Hospital, Department of Urology, Seoul, Korea.
Inje University Seoul Paik Hospital · KRKonkuk University Medical Center · KRInje University Sanggye Paik Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of the combination of exercise and TRT on symptoms of late-onset hypogonadism (LOH) and the durability of response after cessation of TRT were investigated. A total of fifty patients with erectile dysfunction (ED) who had a sedentary lifestyle and low serum total testosterone (T) levels were enrolled and followed for 20 weeks. Patients were randomly divided into two groups; all of them received T gel for 12 weeks and it was discontinued for 8 weeks. Patients assigned to Group II were offered a supervised exercise program for 20 weeks. Measurement of serological testing was performed and self-assessment questionnaires and Global Assessment Question (GAQ) were asked. Baseline characteristics and the initial symptom scores showed no significant difference between the two groups. Serum total T levels and the symptom scores were increased at 12 weeks in both groups, and Group II showed better results with statistical significance. There was a decrease in T levels and worsening of symptom scores at week 20 compared to week 12 in both groups, and Group II showed better results with statistical significance. On the GAQ, Group II showed higher ratio of "yes" at week 12 and the same tendency was sustained at week 20 with significant difference between two groups. The combination of exercise and TRT showed significant improvements in serum T levels and LOH symptoms compared to TRT alone. In addition, these improvements were maintained in the combination group with continuous exercise, even after cessation of TRT.

Indexed as

Exercise TherapyAdultAgedCombined Modality TherapyErectile DysfunctionHormone Replacement TherapyHumansMaleMiddle AgedPatient SatisfactionPilot ProjectsProstate-Specific AntigenTestosteroneTreatment OutcomeProstate-Specific AntigenTestosterone

Identifiers

PMID27427553
PMCPMC5566857
OpenAlexW2428742137

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.