ArticleNeuron2016
Selective Inhibition Mediates the Sequential Recruitment of Motor Pools.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Motor neurons organize Drosophila feeding sequences via a disinhibitory cascade.Nature neuroscience · 2026Article
- Complete muscle denervation triggers compensatory sprouting of a bystander tonic motor neuron iniScience · 2026Article
- Inhibitory circuits control leg movements duringeLife · 2026Article
- Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
- Neural substrates of cold nociception ineLife · 2025Article
- Inhibitory circuit motifs in Drosophila larvae generate motor program diversity and variability.PLoS biology · 2025Article
- Article
- STEERING FROM THE REAR: COORDINATION OF CENTRAL PATTERN GENERATORS UNDERLYING NAVIGATION BY ASCENDING INTERNEURONS.bioRxiv : the preprint server for biology · 2024Article
- Neuromuscular basis ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Synchronous multi-segmental activity between metachronal waves controls locomotion speed ineLife · 2023Article
- High-resolution analysis of individualOpen biology · 2023Article
- The connectome of an insect brain.Science (New York, N.Y.) · 2023Article
- Molecular Logic of Synaptic Diversity BetweenbioRxiv : the preprint server for biology · 2023Article
- Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes.Network neuroscience (Cambridge, Mass.) · 2023Article
- Linking neural circuits to the mechanics of animal behavior inFrontiers in neural circuits · 2023Review
- A neuromechanical model for Drosophila larval crawling based on physical measurements.BMC biology · 2022Article
- The two-body problem: Proprioception and motor control across the metamorphic divide.Current opinion in neurobiology · 2022Review
- Critical periods inFrontiers in physiology · 2022Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
Locomotor systems generate diverse motor patterns to produce the movements underlying behavior, requiring that motor neurons be recruited at various phases of the locomotor cycle. Reciprocal inhibition produces alternating motor patterns; however, the mechanisms that generate other phasic relationships between intrasegmental motor pools are unknown. Here, we investigate one such motor pattern in the Drosophila larva, using a multidisciplinary approach including electrophysiology and ssTEM-based circuit reconstruction. We find that two motor pools that are sequentially recruited during locomotion have identical excitable properties. In contrast, they receive input from divergent premotor circuits. We find that this motor pattern is not orchestrated by differential excitatory input but by a GABAergic interneuron acting as a delay line to the later-recruited motor pool. Our findings show how a motor pattern is generated as a function of the modular organization of locomotor networks through segregation of inhibition, a potentially general mechanism for sequential motor patterns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.