ArticleNeuron2016
Multiple Running Speed Signals in Medial Entorhinal Cortex.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed.
- Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Distinct cortical spatial representations learned along disparate visual pathways.Science advances · 2026Article
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- Diversity and sensorimotor specialization of head direction cells in the mouse thalamus.Current biology : CB · 2026Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Gaussian Process Inference Reveals Non-separability of Position and Velocity Tuning in Grid Cells.bioRxiv : the preprint server for biology · 2026Article
- Time or distance encoding by hippocampal neurons via heterogeneous ramping rates.Nature communications · 2025Article
- Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement.Cell reports · 2025Article
- REMI: Reconstructing Episodic Memory During Internally Driven Path Planning.bioRxiv : the preprint server for biology · 2025Article
- Spatial coding dysfunction and network instability in the aging medial entorhinal cortex.Nature communications · 2025Article
- Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025Article
- Speed modulations in grid cell information geometry.Nature communications · 2025Article
- Hippocampus shapes entorhinal cortical output through a direct feedback circuit.Nature neuroscience · 2025Article
- Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer's disease.Scientific reports · 2025Article
- Self-supervised learning of scale-invariant neural representations of space and time.Journal of computational neuroscience · 2025Article
- A systems model of alternating theta sweeps via firing rate adaptation.Current biology : CB · 2025Article
- Navigation: Scanning your future path.Current biology : CB · 2025Article
- Development of the SPEAR Model: Separate Phases of Encoding and Retrieval Are Necessary for Storing Multiple Overlapping Associative Memories.Hippocampus · 2025Review
- Unweaving the Cognitive Map: A Personal History.Hippocampus · 2025Review
- Neural circuits for goal-directed navigation across species.Trends in neurosciences · 2024Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing rate that increases as a function of running speed. Yet it is currently not known whether these are two manifestations of the same speed signal or dissociable signals with potentially different anatomical substrates. We examined coding of running speed in MEC and identified these two speed signals to be independent of each other within individual neurons. The medial septum (MS) is strongly linked to locomotor behavior, and removal of MS input resulted in strengthening of the firing rate speed signal, while decreasing the strength of the oscillatory speed signal. Thus, two speed signals are present in MEC that are differentially affected by disrupted MS input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.