ArticleScientific reports2016
Two fatty acyl reductases involved in moth pheromone biosynthesis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Fatty Acid Origin of Insect Pheromones.Advances in experimental medicine and biology · 2026Review
- Ultrastructure and Transcriptome Analysis of the Larval Integument in Solitary and Gregarious Phases ofInsects · 2025Article
- Identification of Candidate Genes Associated with Type-II Sex Pheromone Biosynthesis in the Tea Geometrid (Insects · 2024Article
- Article
- Differential gene expression in aphids following virus acquisition from plants or from an artificial medium.BMC genomics · 2022Article
- Release of moth pheromone compounds from Nicotiana benthamiana upon transient expression of heterologous biosynthetic genes.BMC biology · 2022Article
- Bioproduction of (Z,E)-9,12-tetradecadienyl acetate (ZETA), the major pheromone component of Plodia, Ephestia, and Spodoptera species in yeast.Pest management science · 2022Article
- Exploring the Terminal Pathway of Sex Pheromone Biosynthesis and Metabolism in the Silkworm.Insects · 2021Article
- Latest Developments in Insect Sex Pheromone Research and Its Application in Agricultural Pest Management.Insects · 2021Review
- Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts.Frontiers in microbiology · 2021Review
- Transcriptome Analysis ofFrontiers in endocrinology · 2021Article
- Production of Long Chain Fatty Alcohols Found in Bumblebee Pheromones byFrontiers in bioengineering and biotechnology · 2020Article
- Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acyl reductases (FARs) constitute an evolutionarily conserved gene family found in all kingdoms of life. Members of the FAR gene family play diverse roles, including seed oil synthesis, insect pheromone biosynthesis, and mammalian wax biosynthesis. In insects, FAR genes dedicated to sex pheromone biosynthesis (pheromone-gland-specific fatty acyl reductase, pgFAR) form a unique clade that exhibits substantial modifications in gene structure and possesses unique specificity and selectivity for fatty acyl substrates. Highly selective and semi-selective 'single pgFARs' produce single and multicomponent pheromone signals in bombycid, pyralid, yponomeutid and noctuid moths. An intriguing question is how a 'single reductase' can direct the synthesis of several fatty alcohols of various chain lengths and isomeric forms. Here, we report two active pgFARs in the pheromone gland of Spodoptera, namely a semi-selective, C14:acyl-specific pgFAR and a highly selective, C16:acyl-specific pgFAR, and demonstrate that these pgFARs play a pivotal role in the formation of species-specific signals, a finding that is strongly supported by functional gene expression data. The study envisages a new area of research for disclosing evolutionary changes associated with C14- and C16-specific FARs in moth pheromone biosynthesis.
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