Evidence map›Paper›PMID 27427309›Full record

ArticleTrends in biochemical sciences2016

Direct Duplex Detection: An Emerging Tool in the RNA Structure Analysis Toolbox.

Chase A Weidmann, Anthony M Mustoe, Kevin M Weeks

Open access · greenAbstract readComment
In one paragraph

Article in Trends in biochemical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Visualization of RNA Structures and Functional Annotations Using ArcPlot.Methods in molecular biology (Clifton, N.J.) · 2027
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  8. RNA base-pairing complexity in living cells visualized by correlated chemical probing.Proceedings of the National Academy of Sciences of the United States of America · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chase A WeidmannDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA.
Anthony M MustoeDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA.
Kevin M WeeksDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA. Electronic address: weeks@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Integrated Training in Cancer Model SystemsT32CA009156 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 1985 to 2020
$19.7M
Structure of the HIV-1 GenomeR01AI068462 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEEKS, KEVIN M · 2006 to 2020
$7.4M
Retroviral Genomic RNA Dimer Structure and FunctionR01GM064803 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEEKS, KEVIN M · 2002 to 2016
$3.7M
Rapid and Generic Discovery of Small Molecule Ligands Targeting RNAR01GM098662 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEEKS, KEVIN M · 2011 to 2014
$1.2M
NCI NIH HHS T32 CA009156NIAID NIH HHS R01 AI068462NIGMS NIH HHS R01 GM064803NIGMS NIH HHS R01 GM098662
6 · The paper itself

Abstract

While a variety of powerful tools exists for analyzing RNA structure, identifying long-range and intermolecular base-pairing interactions has remained challenging. Recently, three groups introduced a high-throughput strategy that uses psoralen-mediated crosslinking to directly identify RNA-RNA duplexes in cells. Initial application of these methods highlights the preponderance of long-range structures within and between RNA molecules and their widespread structural dynamics.

Indexed as

Base PairingRNAThermodynamicsRNA

Identifiers

PMID27427309
PMCPMC5002247
OpenAlexW2470187006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.